In sepsis cytokine-mediated inflammation, clotting cascade activation and glycocalyx
shedding impair both function and structure of the microcirculation, compromising adequate …

Patient survival depends on determining the cause of the underlying condition and treating
the pathology, as well as supportive care until restoration of normal physiology …

Microcirculatory dysfunction has been recently recognized as a key pathophysiologic
process in the evolution of sepsis. In the present review, we discuss fundamental aspects of …

Sepsis is considered as a life-threatening condition with organ dysfunction due to a
dysregulate host response to infection. Septic shock is defined as a subset of sepsis in …

Sepsis is the number one cause of death among critically ill patients and accounts for more
than 215,000 deaths every year in the United States alone. 1, 2 Randomized controlled trials …

Microcirculation plays an important role in the pathogenesis of shock and organ dysfunction,
especially in sepsis. Monitoring microcirculation at the bedside may be used to assess …

Mortality of critically ill patients is driven by severity of the insult, comorbidities, appropriate
treatment, and organ failure. The pathophysiological mechanisms leading to organ failure …

Abnormal microvascular perfusion, including decreased functional capillary density and
increased blood flow heterogeneity, is observed in early stages of the systemic inflammatory …

In this issue of Intensive Care Medicine, Dyson et al.[1] present the results of an
experimental study in which they evaluated the temporal changes in myocardial function …

The microcirculation is the place where oxygen exchanges take place at the organ level.
The microcirculation has been neglected for a long time by clinicians due to technical …