Exposure to adversity is associated with psychiatric disorders, and delineating the
mechanisms underlying the association is critical for optimizing risk identification and …

Importance Adverse life experiences have been proposed to contribute to diverse mental
health problems through an association with corticolimbic functioning. Despite compelling …

Background Early adverse experiences are assumed to affect fundamental processes of
reward learning and decision making. However, computational neuroimaging studies …

BACKGROUND: Cumulative adversity and stress are associated with risk of psychiatric
disorders. While basic science studies show repeated and chronic stress effects on …

Background The early adversity is associated with a series of negative outcomes in
adulthood, and the impact on the cerebral cortex may be one of the fundamental causes of …

Cumulative adversity (CA) increases stress sensitivity and risk of adverse health outcomes.
However, neural mechanisms underlying these associations in humans remain unclear. To …

Introduction Growing evidence suggests that adverse experiences have long-term effects on
executive functioning and underlying neural circuits. Previous work has identified functional …

Characterizing typologies of childhood adversity may inform the development of risk profiles
and corresponding interventions aimed at mitigating its lifelong consequences. A …

Environmental experiences play a critical role in shaping the structure and function of the
brain. Its plasticity in response to different external stimuli has been the focus of research …

It has long been known that early experience can have a profound and long-lasting impact
on the course of human development. Over the past few decades, however, it has …