Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is
crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self …

The presentation of peptide antigens via major histocompatibility complex (MHC) class II
(MHC-II) molecules represents a key step in several crucial processes in the immune …

Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen
genes (HLA) in humans, are the prevailing contributors of genetic susceptibility to …

Fragments of foreign antigen are detected by CD4+ helper T cells via the T cell receptor for
antigen in the context of major histocompatibility complex (MHC) class II molecules. Very few …

To date, the study of the impact of major hystocompatibility complex on autoimmunity has
been prevalently focused on structural diversity of MHC molecules in binding and …

MHC molecules associated with autoimmunity possess known structural features that limit
the repertoire of peptides that they can present. Such limitation gives a selective advantage …

MHC class II molecules (MHC-II) present antigenic fragments acquired in the endocytic route
to the immune system for recognition and activation of CD4+ T cells. This ignites a series of …

Protective/suppressive major histocompatibility complex (MHC) class II alleles have been
identified in humans and mice where they exert a disease-protective and …

The main function of major histocompatibility complex (MHC) class II molecules is to present
processed antigens, which are derived primarily from exogenous sources, to CD4+ T …

Our understanding of the classical MHC class I molecules (MHC class Ia molecules) has
long focused on their extreme polymorphism. These molecules present peptides to T cells …