Targeted delivery of miR-218 via decorated hyperbranched polyamidoamine for liver cancer regression

AM Elfiky, RH Mohamed, FEZ Abd EL-Hakam… - International Journal of …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is one of most common causes of cancer death worldwide.
MicroRNA (miRNA) replacement gene therapy is a novel approach for HCC management …

Biodegradable polymers as a noncoding miRNA nanocarrier for multiple targeting therapy of human hepatocellular carcinoma

C Yang, M Yin, G Xu, WJ Lin, J Chen… - Advanced …, 2019 - Wiley Online Library
Therapeutic strategy based on the restoration of tumor suppressor‐microRNAs (miRNAs) is
a promising approach for cancer therapy, but the low delivery efficiency of miRNA remains a …

Enzymatically synthesized poly (amino-co-ester) polyplexes for systemic delivery of pcDNA-miRNA-214 to suppress colorectal cancer liver metastasis

H Luo, Z Yang, W Wei, Y Li, H Pu, Y Chen… - Journal of Materials …, 2018 - pubs.rsc.org
Liver metastases from colorectal cancer (CRC) are the major cause of cancer-related deaths
in CRC patients. In our previous study, microRNA-214 (miR-214) was identified in CRC …

[HTML][HTML] Gold nanoparticles delivered miR-375 for treatment of hepatocellular carcinoma

HY Xue, Y Liu, JZ Liao, JS Lin, B Li, WG Yuan, RJ Lee… - Oncotarget, 2016 - ncbi.nlm.nih.gov
MiR-375 is a tumor suppressor miRNA that is downregulated in hepatocellular carcinoma
(HCC). However, due to the lack of effective delivery strategies, miR-375 replacement as a …

Delivery of liver-specific miRNA-122 using a targeted macromolecular prodrug toward synergistic therapy for hepatocellular carcinoma

Q Ning, YF Liu, PJ Ye, P Gao, ZP Li… - … applied materials & …, 2019 - ACS Publications
Hepatocellular carcinoma (HCC) poses a great threat to human health. The elegant
combination of gene therapy and chemotherapy by nanocarriers has been repeatedly …

[HTML][HTML] MicroRNA-122 mimic/microRNA-221 inhibitor combination as a novel therapeutic tool against hepatocellular carcinoma

M Hassan, M Elzallat, T Aboushousha… - Non-coding RNA …, 2023 - Elsevier
Abstract Background Therapeutic microRNAs (miRNAs) delivery holds a lot of promise for
treating human malignancies. So, this study was carried out to examine the potential of miR …

[HTML][HTML] MicroRNA‑466 inhibits the aggressive behaviors of hepatocellular carcinoma by directly targeting metadherin Retraction in/10.3892/or. 2022.8357

C Jia, D Tang, C Sun, L Yao, F Li, Y Hu… - Oncology …, 2018 - spandidos-publications.com
Numerous microRNAs (miRNAs) have been demonstrated to be downregulated or
upregulated in hepatocellular carcinoma (HCC) and play important roles in its occurrence …

Systemic Delivery of MicroRNA-101 Potently Inhibits Hepatocellular Carcinoma In Vivo by Repressing Multiple Targets

F Zheng, YJ Liao, MY Cai, TH Liu, SP Chen… - PLoS …, 2015 - journals.plos.org
Targeted therapy based on adjustment of microRNA (miRNA) s activity takes great promise
due to the ability of these small RNAs to modulate cellular behavior. However, the efficacy of …

Phenylboronic acid-functionalized polyamidoamine-mediated miR-34a delivery for the treatment of gastric cancer

Z Song, X Liang, Y Wang, H Han, J Yang, X Fang… - Biomaterials …, 2019 - pubs.rsc.org
In the present research, a tumor-targeted gene carrier, PPP, was constructed through the
modification of phenylboronic acid onto the surface of a polyamidoamine dendrimer, and …

Circ_0004913 Inhibits Cell Growth, Metastasis, and Glycolysis by Absorbing miR-184 to Regulate HAMP in Hepatocellular Carcinoma

M Wu, T Sun, L Xing - Cancer Biotherapy & Radiopharmaceuticals, 2023 - liebertpub.com
Background: Circular RNA (circRNA) can regulate the progression of hepatocellular
carcinoma (HCC). However, the role and potential mechanism of circ_0004913 in HCC are …