The liver is a frontline immune site specifically designed to check and detect potential
pathogens from the bloodstream to maintain a general state of immune …

Abstract Lactoferrin (LF) is an 80-kDa globular glycoprotein with high affinity for metal ions,
particularly for iron. This protein possesses many biological functions, including the binding …

We are in the midst of a worldwide epidemic of chronic kin-1, an important mediator of the
inflammatory response. 13 The hypoferremia caused by interleukin-1 (and perhaps other …

Iron is an essential element for cell survival; it serves as a cofactor for essential enzymes in
oxidative metabolism and (in the form of heme) as the major oxygen transporter in most …

Crucial cellular processes such as DNA synthesis and the generation of ATP require iron.
Viruses depend on iron in order to efficiently replicate within living host cells. Some viruses …

The liver is one of the largest and most functionally diverse organs in the human body. In
addition to roles in detoxification of xenobiotics, digestion, synthesis of important plasma …

Iron is an essential nutrient that is tightly regulated. A principal function of the liver is the
regulation of iron homeostasis. The liver senses changes in systemic iron requirements and …

Historically, iron overload in the liver has been associated with the genetic disorders
hereditary hemochromatosis and thalassemia and with unusual dietary habits. More …

The control over iron availability is crucial under homeostatic conditions and even more in
the case of an infection. This results from diverse properties of iron: first, iron is an important …

Iron is by far the most widespread and essential transition metal, possessing crucial
biological functions for living systems. Despite chemical advantages, iron biology has forced …