The test methods that currently exist for the identification of thyroid hormone system-
disrupting chemicals are woefully inadequate. There are currently no internationally …

It is well documented that thyroid hormone (TH) action is critical for normal brain
development and is mediated by both nuclear and extranuclear pathways. Given this …

Thyroid hormone signaling is highly conserved among all the vertebrates, and appears to be
present in some invertebrates. Both the components that comprise the system and its …

The thyroid hormone (TH) system is involved in several important physiological processes,
including regulation of energy metabolism, growth and differentiation, development and …

Current test strategies to identify thyroid hormone (TH) system disruptors are inadequate for
conducting robust chemical risk assessment required for regulation. The tests rely heavily on …

Thyroid hormones (THs) play critical roles in profound changes in many vertebrates, notably
in mammalian neurodevelopment, although the precise molecular mechanisms of these …

Many aspects of thyroid endocrinology are very well conserved across vertebrate taxa.
These aspects include thyroid hormone chemistry, the mechanism of its synthesis, and the …

In order to minimize risks to human and environmental health, chemical safety assessment
programs are being reinforced with toxicity tests more specifically designed for detecting …

This article reviews current rodent screens and tests to detect thyroid toxicants. Many points
of disruption for thyroid toxicants are outlined and include:(a) changes in serum hormone …

Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …