Inflammatory cytokines are important regulators of metabolism and food intake. Over
production of inflammatory cytokines during bacterial and viral infections leads to anorexia …

Taste buds are chemosensory structures widely distributed on the surface of the oral cavity
and larynx. Taste cells, exposed to the oral environment, face great challenges in defense …

Taste disorders, including taste distortion and taste loss, negatively impact general health
and quality of life. To understand the underlying molecular and cellular mechanisms, we set …

Although inflammatory responses are a critical component in defense against pathogens,
too much inflammation is harmful. Mechanisms have evolved to regulate inflammation …

Bitter taste receptors (T2Rs) are GPCRs involved in detection of bitter compounds by type 2
taste cells of the tongue, but are also expressed in other tissues throughout the body …

Bitter taste receptors (TAS2Rs or T2Rs) belong to the superfamily of seven-transmembrane
G protein–coupled receptors, which are the targets of> 50% of drugs currently on the market …

The mouse bitter taste receptors Tas2r143, Tas2r135, and Tas2r126 are encoded by genes
that cluster on chromosome 6 and have been suggested to be expressed under common …

Background Bitter taste receptors (T2R) have recently been demonstrated to contribute to
sinonasal innate immunity. One T2R, T2R38, regulates mucosal defense against gram …

Over the past decade tremendous progress has been made in understanding the functional
role of bitter taste receptors (T2Rs) and bitter taste perception. This review will cover the …

Inflammation-mediated changes in taste perception can affect health outcomes in patients,
but little is known about the underlying mechanisms. In the present work, we hypothesized …