Innate recognition by neutrophil granulocytes differs between Neisseria gonorrhoeae strains causing local or disseminating infections

A Roth, C Mattheis, P Muenzner, M Unemo… - Infection and …, 2013 - Am Soc Microbiol
Members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family
serve as cellular receptors for Neisseria gonorrhoeae. More specifically, neisserial colony …

Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae

H Sarantis, SD Gray-Owen - Infection and immunity, 2012 - Am Soc Microbiol
Symptomatic infection of humans with Neisseria gonorrhoeae is characterized by a
neutrophil-rich cervical or urethral exudate, suggesting that neutrophils are important both …

Engulfment of Neisseria gonorrhoeae: Revealing Distinct Processes of Bacterial Entry by Individual Carcinoembryonic Antigen-Related Cellular Adhesion Molecule …

SE McCaw, EH Liao, SD Gray-Owen - Infection and immunity, 2004 - Am Soc Microbiol
Individual Neisseria gonorrhoeae colony opacity-associated (Opa) protein variants can bind
up to four different carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) …

Specific binding to differentially expressed human carcinoembryonic antigen-related cell adhesion molecules determines the outcome of Neisseria gonorrhoeae …

EA Islam, VC Anipindi, I Francis… - Infection and …, 2018 - Am Soc Microbiol
The gonococcal Opa proteins are an antigenically variable family of surface adhesins that
bind human carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) …

Variable expression of opa proteins by Neisseria gonorrhoeae influences bacterial association and phagocytic killing by human neutrophils

AM Alcott, LM Werner, CM Baiocco… - Journal of …, 2022 - Am Soc Microbiol
Neisseria gonorrhoeae infection is characterized by local and abundant recruitment of
neutrophils. Despite neutrophils' antimicrobial activities, viable N. gonorrhoeae is recovered …

Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on primary …

P Muenzner, M Naumann, TF Meyer… - Journal of Biological …, 2001 - ASBMB
Neisseria gonorrhoeae express opacity-associated (Opa) protein adhesins that mediate
binding to various members of the carcinoembryonic antigen-related cellular adhesion …

CEACAM1 dynamics during Neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation

HSW Lee, MA Ostrowski… - The Journal of …, 2008 - journals.aai.org
Neisseria gonorrhoeae colony opacity-associated (Opa) proteins bind to human
carcinoembryonic antigen cellular adhesion molecules (CEACAM) found on host cells …

Imaging Flow Cytometry Analysis of CEACAM Binding to Opa‐Expressing Neisseria gonorrhoeae

LM Werner, A Palmer, A Smirnov… - Cytometry Part …, 2020 - Wiley Online Library
Human carcinoembryonic antigen‐related cell adhesion molecules (CEACAMs) are a family
of receptors that mediate intercellular interactions. Pathogenic bacteria have ligands that …

CEACAM is not necessary for Neisseria gonorrhoeae to adhere to and invade female genital epithelial cells

KV Swanson, GA Jarvis, GF Brooks… - Cellular …, 2001 - Wiley Online Library
Neisseria gonorrhoeae has a repertoire of up to 11 opacity‐associated (Opa) proteins that
are adhesins. Most Opa proteins adhere to CEACAM antigens and when CEACAM …

Selection for a CEACAM receptor-specific binding phenotype during Neisseria gonorrhoeae infection of the human genital tract

A Sintsova, H Wong, KS MacDonald, R Kaul… - Infection and …, 2015 - Am Soc Microbiol
Infections by Neisseria gonorrhoeae are increasingly common, are often caused by
antibiotic-resistant strains, and can result in serious and lasting sequelae, prompting the …