Toxicity assessment of metal oxide nanomaterials using in vitro screening and murine acute inhalation studies

S Areecheewakul, A Adamcakova-Dodd, BE Givens… - NanoImpact, 2020 - Elsevier
Characterizations and in vitro toxicity screening were performed on metal oxide engineered
nanomaterials (ENMs) independently comprising ZnO, CuO, CeO 2, Fe 2 O 3, WO 3, V 2 O …

A practical approach to assess inhalation toxicity of metal oxide nanoparticles in vitro

ACA Dankers, CF Kuper, AJ Boumeester… - Journal of Applied …, 2018 - Wiley Online Library
Exposure of humans to metal oxide nanoparticles (NPs) occurs mainly via air, and inhaled
metal oxide NPs may generate inflammation. The aim of this study was to investigate the …

[HTML][HTML] Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials

R Landsiedel, L Ma-Hock, T Hofmann… - Particle and fibre …, 2014 - Springer
Background A standard short-term inhalation study (STIS) was applied for hazard
assessment of 13 metal oxide nanomaterials and micron-scale zinc oxide. Methods Rats …

Airway irritation, inflammation, and toxicity in mice following inhalation of metal oxide nanoparticles

ST Larsen, P Jackson, SS Poulsen, M Levin… - …, 2016 - Taylor & Francis
Metal oxide nanoparticles are used in a broad range of industrial processes and workers
may be exposed to aerosols of the particles both during production and handling. Despite …

Organ burden and pulmonary toxicity of nano-sized copper (II) oxide particles after short-term inhalation exposure

I Gosens, FR Cassee, M Zanella, L Manodori… - …, 2016 - Taylor & Francis
Introduction: Increased use of nanomaterials has raised concerns about the potential for
undesirable human health and environmental effects. Releases into the air may occur and …

[HTML][HTML] Acute phase response following pulmonary exposure to soluble and insoluble metal oxide nanomaterials in mice

CT Gutierrez, C Loizides, I Hafez, A Brostrøm… - Particle and Fibre …, 2023 - Springer
Background Acute phase response (APR) is characterized by a change in concentration of
different proteins, including C-reactive protein and serum amyloid A (SAA) that can be linked …

[HTML][HTML] Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice

I Gosens, A Kermanizadeh, NR Jacobsen, AG Lenz… - PloS one, 2015 - journals.plos.org
Comparative hazard identification of nanomaterials (NMs) can aid in the prioritisation for
further toxicity testing. Here, we assessed the acute lung, systemic and liver responses in …

In Vitro Aerosol Exposure to Nanomaterials: From Laboratory to Environmental Field Toxicity Testing

TB Tilly, MT Nelson, KB Chakravarthy… - Chemical Research …, 2019 - ACS Publications
Exposure to nanomaterials (NMs) is inevitable, requiring robust toxicological assessment to
understand potential environmental and human health effects. NMs are favored in many …

[HTML][HTML] Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice

JD Sisler, R Li, W McKinney, RR Mercer, Z Ji… - Particle and fibre …, 2015 - Springer
Background Although classified as metal oxides, cobalt monoxide (CoO) and lanthanum
oxide (La 2 O 3) nanoparticles, as representative transition and rare earth oxides, exhibit …

Testing metal‐oxide nanomaterials for human safety

R Landsiedel, L Ma‐Hock, A Kroll, D Hahn… - Advanced …, 2010 - Wiley Online Library
Nanomaterials can display distinct biological effects compared with bulk materials of the
same chemical composition. The physico‐chemical characterization of nanomaterials and …