The number of patients with end-stage renal failure is increasing annually worldwide and
the problem is compounded by a shortage of renal transplantation donors. In our previous …

It has been a challenge in developmental biology and regenerative medicine to generate
nephron progenitors that reconstitute the three-dimensional (3D) nephron structure in vitro …

The kidney is an important organ for maintenance of homeostasis in the human body. As
renal failure progresses, renal replacement therapy becomes necessary. However, there is …

Although renal transplantation has proved a successful treatment for the patients with end-
stage renal failure, the therapy is hampered by the problem of serious shortage of donor …

Kidney tissue can be generated from human mouse pluripotent stem cells or MSCs by
several methods. The size and function of regenerated kidney tissue do not meet the …

Nephron progenitors in the embryonic kidney propagate while generating differentiated
nephrons. However, in mice, the progenitors terminally differentiate shortly after birth. Here …

Kidney regeneration is expected to be a new alternative treatment to the currently limited
treatments for chronic kidney disease. By transplanting exogeneous nephron progenitor …

Studies of kidney regeneration using stem cells have progressed rapidly in recent years. Our
group has developed a protocol to induce nephron progenitors from both mouse and human …

Animal fetuses and embryos may have applications in the generation of human organs.
Progenitor cells may be an appropriate cell source for regenerative organs because of their …

It is believed that the development of new renal replacement therapy (RRT) will increase
treatment options for end-stage kidney disease and help reduce the mismatch between …