Studying monogenic hereditary disorders that manifest age-related phenotypes in cells,
tissues, and the total organism would be helpful for clarifying the mechanisms of aging. In …

Recent progress in pharmaceutical sciences has made it possible for us to live longer and
longer. For example, antibiotics and vaccines have been developed that were successfully …

Werner syndrome is a rare autosomal recessive disorder that mimics some of the
characteristics of aging. The gene for this disorder has recently been identified as a helicase …

The RecQ family of DNA helicases have potential roles in DNA repair, replication and/or
recombination pathways. In humans, a defect in the RecQ family helicases encoded by the …

Six known or predicted helicases that are mutated in human syndromes are now
recognized. These syndromes include xeroderma pigmentosum, Cockayne's syndrome …

The list of human RecQ helicase comprises RecQ1, BLM (Bloom syndrome), WRN (Werner
syndrome), RTS (Rothmund-Thomson syndrome), and RecQ5. Of these, the defective BLM …

Werner's syndrome (WS) is a valuable model of accelerated ageing and results from
mutations in a recQ helicase (wrn). WS fibroblasts show a mutator phenotype, replication …

Patients who have the rare hereditary condition known as Werner's syndrome begin aging
dramatically while still in their twenties. Their hair goes gray, their skin loses its suppleness …

There is ample evidence from studies of both unicellular and multicellular organisms that
helicase-inactivating mutations lead to cellular dysfunction and disease phenotypes. In this …

The Werner and Bloom syndromes are caused by loss-of-function mutations in WRN and
BLM, respectively, which encode the RecQ family DNA helicases WRN and BLM …