Abstract Background and Objective Piperacillin/tazobactam is one of the most frequently
used antimicrobials in older adults. Using an opportunistic study design, we evaluated the …

Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very
elderly patients. This study aimed to conduct a population pharmacokinetic analysis of CI …

The aim of this study was to develop a population pharmacokinetic model for piperacillin
(PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the …

While extended infusions of piperacillin-tazobactam (TZP) are increasingly used in practice,
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …

The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …

Objective The study was to establish a population pharmacokinetic (PPK) model of
piperacillin (PIP) and tazobactam (TAZ) that explain pharmacokinetic variability and to …

Abstract Background and Objectives Although dose optimization studies have been
performed for piperacillin and tazobactam separately, a combined integral analysis is not yet …

Objectives To evaluate the pharmacokinetics of piperacillin/tazobactam in critically ill
patients undergoing continuous renal replacement therapy (CRRT) and to assess the …

Piperacillin in combination with tazobactam is one of the most commonly used intravenous
antibiotics. There is evidence for a possible saturable elimination of piperacillin. Therefore …