Pathological pain is regulated by a balance between pro-algesic and analgesic
mechanisms. Interactions between opioid peptide-producing immune cells and peripheral …

Neuropathic pain is a compilation of somatosensory, cognitive and emotional alterations
developing following nerve injuries. Such pain often outlasts the initial cause and becomes …

Classically, pain sensation or suppression has been attributed exclusively to neuronal
circuits. This review challenges this notion and presents an expanded concept about the …

This review summarizes recent findings on neuro-immune mechanisms underlying opioid-
mediated inhibition of pain. The focus is on events occurring in peripheral injured tissues …

The analgesic effects of leukocyte-derived opioids have been exclusively demonstrated for
somatic inflammatory pain, for example, the pain associated with surgery and arthritis …

In peripheral inflamed tissue interactions between leukocyte-derived opioid peptides and
opioid receptors on sensory neurons lead to potent, clinically relevant inhibition of pain …

Ability to perceive physiological pain is essential in protecting the individual from tissue
destruction. In contrast, pathological chronic pain is an expression of maladaptive alterations …

Recent findings have suggested a significant involvement of the immune system in the
control of pain. Immune cells contain opioid peptides that are released within inflamed tissue …

It is accepted that inflammatory mediators released from leukocytes contribute to the
generation of pain. However, it is less well known that immune cells also produce mediators …

Immune Mechanisms of Pain and Analgesia is the first volume to discuss a new concept of
immune-neural interplays leading to pain or analgesia. It argues the classical view that pain …