Behind the scenes: nod-like receptor X1 controls inflammation and metabolism
Regulatory Nod-like receptors (NLRs) are a subgroup of the cytosolic NLR family of
pathogen recognition receptors (PRRs). These receptors can tune the innate immune …
pathogen recognition receptors (PRRs). These receptors can tune the innate immune …
NLR in eXile: Emerging roles of NLRX1 in immunity and human disease
RJ Pickering, LM Booty - Immunology, 2021 - Wiley Online Library
NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …
NLRX1 is a mitochondrial NOD‐like receptor that amplifies NF‐κB and JNK pathways by inducing reactive oxygen species production
I Tattoli, LA Carneiro, M Jéhanno, JG Magalhaes… - EMBO …, 2008 - embopress.org
NOD‐like receptors (NLRs) are a family of intracellular sensors of microbial‐or danger‐
associated molecular patterns. Here, we report the identification of NLRX1, which is a new …
associated molecular patterns. Here, we report the identification of NLRX1, which is a new …
The regulatory role of NLRX1 in innate immunity and human disease
M Liu, K Liu, D Cheng, B Zheng, S Li, Z Mo - Cytokine, 2022 - Elsevier
Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …
Focusing on the cell type specific regulatory actions of NLRX1
Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect
exogenous or endogenous danger signals and even the changes of their microenvironment …
exogenous or endogenous danger signals and even the changes of their microenvironment …
Role of NOD-like receptors in infectious and immunological diseases
CR Lupfer, PK Anand, X Qi, H Zaki - Frontiers in immunology, 2020 - frontiersin.org
NOD-like Receptors (NLRs) are a large family of 22 intracellular proteins in humans.
Although NLRs are structurally homologous to each other, they perform a diverse array of …
Although NLRs are structurally homologous to each other, they perform a diverse array of …
Underlying mechanisms and related diseases behind the complex regulatory role of NOD-like receptor X1
H Shi, ZM Zhou, L Zhu, L Chen, ZL Jiang… - DNA and Cell …, 2022 - liebertpub.com
Among nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), NOD-like
receptor X1 (NLRX1) is the only known NLR family member that is targeted to the …
receptor X1 (NLRX1) is the only known NLR family member that is targeted to the …
NOD-like receptors: role in innate immunity and inflammatory disease
The NOD-like receptors (NLRs) are a specialized group of intracellular receptors that
represent a key component of the host innate immune system. Since the discovery of the first …
represent a key component of the host innate immune system. Since the discovery of the first …
Unleashing the therapeutic potential of NOD-like receptors
K Geddes, JG Magalhaes, SE Girardin - Nature reviews Drug discovery, 2009 - nature.com
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are a family of
intracellular sensors that have key roles in innate immunity and inflammation. Whereas …
intracellular sensors that have key roles in innate immunity and inflammation. Whereas …
Nod-like receptors: critical intracellular sensors for host protection and cell death in microbial and parasitic infections
AO Babamale, ST Chen - International journal of molecular sciences, 2021 - mdpi.com
Cell death is an essential immunological apparatus of host defense, but dysregulation of
mutually inclusive cell deaths poses severe threats during microbial and parasitic infections …
mutually inclusive cell deaths poses severe threats during microbial and parasitic infections …