Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility
complex (MHC) I complexes from antigens they have collected from cells in tissues and …

It was originally thought that a cell's major histocompatibility complex (MHC) class I
molecules presented peptides derived exclusively from proteins synthesized by the cell …

During the processing of particulate Ags, it is unclear whether peptide: class II MHC (MHC-II)
complexes are formed within phagosomes or within endocytic compartments that receive Ag …

Highlights•Dendritic cells internalize exogenous antigens for cross-presentation on MHC
I.•MHC I cross-presentation allows immune surveillance of viral infection and …

B cells, dendritic cells and macrophages present peptides derived from exogenous antigens
to CD4+ T cells. After uptake, antigens are processed into peptides, bound to major …

The association between antigenic peptides and MHC class II molecules represents a
critical event in the initiation of the immune response to extracellular antigens …

▪ Abstract Class I and class II MHC molecules bind peptides during their biosynthetic
maturation and provide a continuously updated display of intracellular and environmental …

Peptides presented by MHC class I molecules are mostly derived from proteins synthesized
by the antigen‐presenting cell itself, while peptides presented by MHC class II molecules …

Phagosomes contain class II MHC (MHC-II) and form peptide: MHC-II complexes, but the
source of phagosomal MHC-II molecules is uncertain. Phagosomes may acquire nascent …

During MHC‐I‐restricted antigen processing, peptides generated by cytosolic proteasomes
are translocated by the transporter associated with antigen processing (TAP) into the …