Human spermatogonial stem cells (SSCs) are an essential source to maintain
spermatogenesis as an efficient process for daily sperm production with high self-renewal …

Spermatogonial stem cells (SSCs) are essential for adult spermatogenesis. Recently, Wang
et al.(2018), Guo et al.(2018), and Hermann et al.(2018) used single-cell RNA sequencing to …

Antineoplastic treatments for cancer and other non-malignant disorders can result in long-
term or permanent male infertility by ablating spermatogonial stem cells (SSCs). SSC …

Spermatogonial stem cells (SSCs) are crucial for maintaining spermatogenesis throughout
life, and understanding how these cells function has important implications for …

Abstract Background Spermatogonial stem cells (SSCs) are the foundation cells for
continual spermatogenesis and germline regeneration in mammals. SSC activities reside in …

Spermatogenesis is maintained by a pool of spermatogonial stem cells (SSCs). Analyses of
the molecular profile of SSCs have revealed the existence of subsets, indicating that the …

Male infertility is responsible for approximately half of all cases of reproductive issues.
Spermatogenesis originates in a small pool of spermatogonial stem cells (SSCs), which are …

Human male infertility has become a major health and social concern worldwide, and this is
being increasingly realized as cancer survival rates improve. It is estimated that the …

BACKGROUND A key step in studying the biology of spermatogonia is to determine their
global gene expression profile. However, disassociation of these cells from the testis may …

Objective To determine the molecular characteristics of human spermatogonia and optimize
methods to enrich spermatogonial stem cells (SSCs). Design Laboratory study using human …