Crohn's disease (CD) is a chronic disorder characterized by full thickness patchy
inflammation of the gastrointestinal tract. The pathogenesis is multifactorial and involves …

Crohn's disease (CD) is characterized by inflammation that can affect any part of the
gastrointestinal tract. It is a chronic destructive condition that follows a relapsing–remitting …

Tumor necrosis factor (TNF) is a pleotropic cytokine involved in a wide range of pathological
processes, including inflammatory bowel disease (IBD). In the past, TNF was recognized as …

Crohn's disease (CD) accounts for a variety of clinical manifestations or phenotypes that
stem from chronic inflammation in the gastrointestinal tract. Its worldwide incidence is …

Crohn's disease is a complex multifactorial disorder characterized by the alternation of a
cytokine-driven Tlymphocyte-depending inflammation of the intestinal mucosa, and “off” …

Background While monoclonal antibodies against tumor necrosis factor-α (TNFα) are
effective in treating Crohn's disease (CD), approximately one-third of patients lose response …

Tumor necrosis factor-alpha (TNF alpha) is one of several pro-inflammatory cytokines that
have been implicated in the pathogenesis of Crohn's disease (CD). Treatment with …

Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases
(IBD) and have pathophysiological processes such as bowel necrosis and enteric neurons …

Crohn's disease (CD) is a chronic inflammatory disorder which may involve any part of
gastrointestinal tract. Chronic inflammation is primarily due to an immunological imbalance …

The most prominent treatment for the serious cases of Crohn's disease (CD) are biological
tumour necrosis factor (TNF) inhibitors. Unfortunately, therapy nonresponse is still a serious …