Application of CRISPR in filamentous fungi and macrofungi: from component function to development potentiality

JY Shen, Q Zhao, QL He - ACS Synthetic Biology, 2023 - ACS Publications
Fungi, particularly filamentous fungi and macrofungi, have a very powerful ability to produce
secondary metabolites and can serve as excellent chassis cells for the production of …

CRISPR/Cas9-based genome editing of the filamentous fungi: the state of the art

TQ Shi, GN Liu, RY Ji, K Shi, P Song, LJ Ren… - Applied microbiology …, 2017 - Springer
In recent years, a variety of genetic tools have been developed and applied to various
filamentous fungi, which are widely applied in agriculture and the food industry. However …

Development of a versatile and conventional technique for gene disruption in filamentous fungi based on CRISPR-Cas9 technology

YM Zheng, FL Lin, H Gao, G Zou, JW Zhang… - Scientific reports, 2017 - nature.com
Filamentous fungi represent an invaluable source of pharmaceutically active compounds.
The development of versatile methods to genetically manipulate filamentous fungi is of great …

CRISPR/Cas9 genome editing technology in filamentous fungi: progress and perspective

R Song, Q Zhai, L Sun, E Huang, Y Zhang… - Applied microbiology …, 2019 - Springer
Filamentous fungi play an important role in human health and industrial/agricultural
production. With the increasing number of full genomes available for fungal species, the …

Progress and challenges: development and implementation of CRISPR/Cas9 technology in filamentous fungi

Q Wang, JJ Coleman - Computational and structural biotechnology journal, 2019 - Elsevier
Widely distributed in various environmental niches, filamentous fungi play an important role
in industry, drug development, and plant/animal health. Manipulation of the genome and the …

CRISPR/Cas9‐based genome engineering: A new breakthrough in the genetic manipulation of filamentous fungi

M Ullah, L Xia, S Xie, S Sun - Biotechnology and Applied …, 2020 - Wiley Online Library
Filamentous fungi have several industrial, environmental, and medical applications.
However, they are rarely utilized owing to the limited availability of full‐genome sequences …

CRISPR/Cas9-Based Genome Editing and Its Application in Aspergillus Species

FJ Jin, BT Wang, ZD Wang, L Jin, P Han - Journal of Fungi, 2022 - mdpi.com
Aspergillus, a genus of filamentous fungi, is extensively distributed in nature and plays
crucial roles in the decomposition of organic materials as an important environmental …

[HTML][HTML] CRISPR-Cas9 genome editing approaches in filamentous fungi and oomycetes

M Schuster, R Kahmann - Fungal Genetics and Biology, 2019 - Elsevier
Due to their biotechnological relevance as well as their importance as disease agents,
filamentous fungi and oomycetes have been prime candidates for genetic selection and in …

Molecular tools for gene manipulation in filamentous fungi

S Wang, H Chen, X Tang, H Zhang, W Chen… - Applied microbiology …, 2017 - Springer
Functional genomics of filamentous fungi has gradually uncovered gene information for
constructing 'cell factories' and controlling pathogens. Available gene manipulation methods …

Applications of CRISPR/Cas9 in the synthesis of secondary metabolites in filamentous fungi

C Jiang, G Lv, Y Tu, X Cheng, Y Duan… - Frontiers in …, 2021 - frontiersin.org
Filamentous fungi possess the capacity to produce a wide array of secondary metabolites
with diverse biological activities and structures, such as lovastatin and swainsonine. With the …