Molecular regulation of copper homeostasis in the male gonad during the process of spermatogenesis

S Herman, P Lipiński, M Ogórek, R Starzyński… - International journal of …, 2020 - mdpi.com
Owing to its redox properties, copper is a cofactor of enzymes that catalyze reactions in
fundamental metabolic processes. However, copper–oxygen interaction, which is a source …

[HTML][HTML] Role of copper in the process of spermatogenesis

M Ogórek, Ł Gąsior, O Pierzchała… - Advances in Hygiene …, 2017 - phmd.pl
Copper (Cu) is an essential trace element required for the normal development of living
organisms. Due to its redox potential, copper is a cofactor in many enzymes responsible for …

Iron and copper in male reproduction: a double-edged sword

E Tvrda, R Peer, SC Sikka, A Agarwal - Journal of assisted reproduction …, 2015 - Springer
Iron and copper are essential trace nutrients playing important roles in general health and
fertility. However, both elements are highly toxic when accumulating in large quantities …

Atp7a and Atp7b regulate copper homeostasis in developing male germ cells in mice

M Ogórek, M Lenartowicz, R Starzyński, A Jończy… - Metallomics, 2017 - academic.oup.com
The maintenance of copper homeostasis is critical for all cells. As learned from mice with
disturbed copper metabolism, this trace element is also important for spermatogenesis. The …

Copper transporter 1 (CTR1) expression by mouse testicular germ cells, but not Sertoli cells, is essential for functional spermatogenesis

R Ghaffari, KR Di Bona, CL Riley, JH Richburg - PLoS One, 2019 - journals.plos.org
An imbalance in copper (Cu) tissue homeostasis has a degenerative effect on
spermatogenesis and male fertility. The high-affinity Cu transporter 1 (CTR1; SLC31A1) is …

Effects of zinc deficiency on impaired spermatogenesis and male infertility: the role of oxidative stress, inflammation and apoptosis

AB Harchegani, H Dahan, E Tahmasbpour… - Human …, 2018 - Taylor & Francis
Zinc (Zn) is necessary for the normal function of the male reproductive system and
spermatozoa. Although influences of zinc deficiency on impaired spermatogenesis and male …

Role of zinc (Zn) in human reproduction: A journey from initial spermatogenesis to childbirth

S Vickram, K Rohini, S Srinivasan… - International journal of …, 2021 - mdpi.com
Zinc (Zn), the second-most necessary trace element, is abundant in the human body. The
human body lacks the capacity to store Zn; hence, the dietary intake of Zn is essential for …

Copper trafficking to the secretory pathway

S Lutsenko - Metallomics, 2016 - academic.oup.com
Copper (Cu) is indispensible for growth and development of human organisms. It is required
for such fundamental and ubiquitous processes as respiration and protection against …

A novel functional role of nickel in sperm motility and eukaryotic cell growth

J Bian, X Shi, Q Li, M Zhao, L Wang, J Lee… - Journal of Trace …, 2019 - Elsevier
Background Metal ions are essential for numerous life processes. This study aims to
investigate the relationship between seminal quality and ion levels in seminal plasma. Basic …

Zinc: A necessary ion for mammalian sperm fertilization competency

K Kerns, M Zigo, P Sutovsky - International journal of molecular sciences, 2018 - mdpi.com
The importance of zinc for male fertility only emerged recently, being propelled in part by
consumer interest in nutritional supplements containing ionic trace minerals. Here, we …