Introduction: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterised by
insulin resistance. The prevalence of T2DM is increasing with an estimated 14.2 million …

The asymptomatic nature of and lack of effective early-stage diagnostic tools in CKD,
predisposes individuals to the risk of end-stage CKD and related complications. Whole …

Background: Chronic kidney disease (CKD) is a major public health concern and contributor
to morbidity and mortality globally. Identification of CKD in its early stages is critical to …

Aims MicroRNAs (miRNAs) from extracellular vesicles (EVs) have been proposed as
promising biomarkers for a number of diseases. In this study, their potential as urine-based …

OBJECTIVES/GOALS: This study aimed to characterize urinary exosomal miRNA content in
African American adults with diabetic kidney disease. METHODS/STUDY POPULATION …

Introduction: Diabetic kidney disease (DKD) remains the leading cause of chronic kidney
disease. Dysregulation of circulating miRNAs has been reported, suggesting their …

The burden of chronic kidney disease (CKD) in Africa remains poorly characterized, due
partly to the lack of appropriate diagnostic strategies. Although in recent years the diagnostic …

Background: There has been a gradual increase in the prevalence of type 2 diabetes
mellitus (T2DM) in South Africa, and in 2019, the prevalence was reported to be the highest …

Purpose Currently available markers for early detection of diabetic nephropathy (DN), the
leading cause of end stage renal disease, have some limitations. There is insufficient …

Aim: The influence of disease duration and anti-diabetic treatment on epigenetic processes
has been described, with limited focus on interactions with microRNAs (miRNAs). miRNAs …