Prostate cancer (PC) has the highest degree of genetic transmission of any form of
malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal …

Prostate cancer is the most commonly diagnosed cancer among men in the United States as
well as most Western countries. A significant proportion of men report having a positive …

Improvements in DNA sequencing technology and discoveries made by large scale genome-
wide association studies have led to enormous insight into the role of genetic variation in …

The search for susceptibility loci in hereditary prostate cancer (HPC) has proven challenging
due to genetic and disease heterogeneity. Multiple risk loci have been identified to date …

A significant proportion of prostate cancer diagnoses may be associated with a strong
hereditary component. Men who have multiple single‐gene polymorphisms and a family …

BACKGROUND Although the subject of intensive study, the genetic influences responsible
for familial clustering of prostate cancer remain largely unidentified. Genome‐wide scans for …

Background: Prostate cancer represents a substantial public health burden worldwide. It is
the second leading cause of cancer death among men in the United States. A family history …

This presentation reviews data on the familial component of prostate cancer and evidence to
support a role of genetic susceptibility in this common and complex disease. Data from case …

Evidence of the existence of major prostate cancer (PC)–susceptibility genes has been
provided by multiple segregation analyses. Although genomewide screens have been …

Prostate cancer (PCa) remains the most common cancer in men. The proportion of all PCa
attributable to high-risk hereditary factors has been estimated to 5–15%. Recent landmark …