[HTML][HTML] Is there a role for gut microbiome dysbiosis in IgA nephropathy?

RC Monteiro, D Rafeh, PJ Gleeson - Microorganisms, 2022 - mdpi.com
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis and
one of the leading causes of renal failure worldwide. The pathophysiology of IgAN involves …

[HTML][HTML] ISN forefronts symposium 2015: IgA nephropathy, the gut microbiota, and gut− kidney crosstalk

L Han, X Fang, Y He, XZ Ruan - Kidney International Reports, 2016 - Elsevier
IgA nephropathy (IgAN) represents the most common form of primary glomerulonephritis
worldwide, especially in East Asia; even with current treatments, it can lead to end-stage …

The microbiome and IgA nephropathy

K Haniuda, JL Gommerman, HN Reich - Seminars in Immunopathology, 2021 - Springer
The immunopathogenic mechanisms underlying immunoglobulin A nephropathy (IgAN) are
poorly understood, yet it is one of the most common causes of kidney failure globally. The …

[HTML][HTML] Fecal microbiota transplantation modulates renal phenotype in the humanized mouse model of IgA nephropathy

G Lauriero, L Abbad, M Vacca, G Celano… - Frontiers in …, 2021 - frontiersin.org
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis.
Several observations suggest that gut microbiota could be implicated in IgAN …

Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice

JM Chemouny, PJ Gleeson, L Abbad… - Nephrology Dialysis …, 2019 - academic.oup.com
Abstract Background Immunoglobulin A nephropathy (IgAN) is the most common primary
glomerulonephritis worldwide. IgA is mainly produced by the gut-associated lymphoid tissue …

The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis

PJ Gleeson, N Benech, J Chemouny… - Science Translational …, 2024 - science.org
Mechanisms underlying the disruption of self-tolerance in acquired autoimmunity remain
unclear. Immunoglobulin A (IgA) nephropathy is an acquired autoimmune disease where …

Alleviation of refractory IgA nephropathy by intensive fecal microbiota transplantation: The first case reports

J Zhao, M Bai, X Yang, Y Wang, R Li, S Sun - Renal Failure, 2021 - Taylor & Francis
Background Gut dysbiosis may be implicated in the pathogenesis of IgA nephropathy (IgAN)
through immune and/or metabolite pathways. Fecal microbiota transplantation (FMT) could …

[HTML][HTML] Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies

JW He, XJ Zhou, JC Lv, H Zhang - Theranostics, 2020 - ncbi.nlm.nih.gov
Infections have been considered to play a critical role in the pathogenesis of IgA
nephropathy (IgAN) because synpharyngitic hematuria is a common feature in IgAN …

IgA nephropathy: a perspective for 2021

J Floege, J Barratt - Seminars in Immunopathology, 2021 - Springer
Immunoglobulin A nephropathy (IgAN) is the commonest primary glomerular disease
worldwide and responsible for a significant proportion of the global end-stage kidney …

[HTML][HTML] Aberrant Gut Microbiome Contributes to Barrier Dysfunction, Inflammation, and Local Immune Responses in IgA Nephropathy

Y Tang, Y Xiao, H He, Y Zhu, W Sun, P Hu… - Kidney and Blood …, 2023 - karger.com
Introduction: Numerous research works have shown that serum Gal-deficient (Gd) IgA1
levels are increased in IgA nephropathy (IgAN) patients and these levels are a dangerous …