It has been 30 years since the first member of the protease-activated receptor (PAR) family
was discovered. This was followed by the discovery of three other receptors, including …

Of all the body systems, the gastrointestinal (GI) tract is the most exposed to proteinases.
Proteolytic activity must thus be tightly regulated in the face of diverse environmental …

Two regulatory elements of the exo-crine pancreas, one new and one old, may interact to
regulate previously undescribed physiological and pathological responses of the pancreas …

It has been almost a decade since the molecular cloning of all four members of the
proteinase‐activated receptor (PAR) family was completed. This unique family of G protein …

Proteinase‐activated receptors (PARs) have the common property of being activated by the
proteolytic cleavage of their extracellular N‐terminal domain. The new NH2‐terminus acts as …

Protease-activated receptor-2 (PAR-2) is a widely expressed tethered ligand receptor that
can be activated by trypsin and other trypsin-like serine proteases. In the exocrine pancreas …

PARs (protease-activated receptors) are a family of four G-protein-coupled receptors for
proteases from the circulation, inflammatory cells and epithelial tissues. This report focuses …

Protease-activated receptor-2 (PAR2) is a 7-transmembrane G-protein-coupled tethered
ligand receptor that is expressed by pancreatic acinar and ductal cells. It can be …

Background: Protease-activated receptor-2 (PAR-2) is present in the pancreas, where it has
been shown to play a protective role during pancreatitis. However, the mechanism by which …

PAR-2 (protease-activated receptor 2), a G-protein-coupled receptor activated by certain
serine proteases such as trypsin and tryptase, is now considered a physiologically important …