Introduction During postherpetic neuralgia (PHN), the cerebral spinal fluid (CSF) possesses
the capability to trigger glial activation and inflammation, yet the specific changes in its …

Background Neuropathic pain (NP) is known to be highly correlated with microglial
polarization, of which the regulatory mechanism remains to be elucidated. Here, the aim of …

Inflammatory and neurotrophic factors are involved in postherpetic neuralgia (PHN), but the
association of these factors in the cerebrospinal fluid (CSF) with the level of pain is poorly …

Background Bone morphogenetic protein-2/4 (BMP2/4) has been recognized as promoters
of astrocyte activity. Substantial evidence suggests that BMP2/4 may be elevated and plays …

Burn injury-induced pain (BIP) is an extremely complicated condition usually resistant to
analgesic drugs, while its pathogenesis remains unknown. Considerable attention has been …

Background Postherpetic pain (PHP) is difficult to control. Although Neurotropin®(NTP) and
methylcobalamin (MCB) are often prescribed to treat the pain, the efficacy of combined …

Postherpetic neuralgia (PHN), the most common complication of herpes zoster (HZ), plays a
major role in decreased life quality of HZ patients. However, the neural mechanisms …

The intrinsic mechanism of postherpetic neuralgia (PHN) remains unclear. Herein, we aimed
to seek the hub proteins in the cerebrospinal fluid (CSF), which display significant changes …

Background BMP7 has been shown to have neuroprotective effects and to alleviate
demyelination. However, its role in trigeminal neuralgia (TN) has not been well investigated …

Deafferentation pain (DP), a typical neuropathic pain, occurs due to peripheral or central
sensory nerve injury, which causes abnormal discharge of the upstream neurons or C fibers …