[PDF][PDF] Targeting Proteostasis in Multiple Myeloma

A Subramaniam - 2022 - duo.uio.no
Multiple myeloma (MM) is characterized by the expansion of malignant plasma cells in the
bone marrow. These transformed plasma cells are highly biosynthetic thereby producing …

[PDF][PDF] Targeting protein synthesis and degradation in multiple myeloma: a look at what's on the horizon

MHZ Guang, G Bianchi - Am J Hematol Oncol, 2017 - gotoper-com.s3.amazonaws.com
The natural history of multiple myeloma (MM) has profoundly changed over the last 20
years, largely due to the introduction of novel agents targeting MM in the context of the bone …

Preclinical Overview of Drugs Affecting Protein Turnover in Multiple Myeloma

G Bianchi, M Ho, KC Anderson - Precision Cancer Therapies …, 2023 - Wiley Online Library
Multiple myeloma (MM) is the prototypic cancer model for proteotoxicity due to the extensive
and sustained synthesis of immunoglobulin or free light chain in the face of insufficient …

Proteomic and metabolic reprogramming in myeloma cells within the tumor microenvironment

E Milan, A Gullà - Frontiers in Oncology, 2023 - frontiersin.org
Multiple myeloma (MM) is a hematological malignancy characterized by the dysregulated
proliferation of transformed plasma cells (PCs) primarily in the bone marrow (BM)(1). For the …

A wholesale approach to disarm multiple myeloma

S Cenci - Blood Advances, 2023 - ashpublications.org
In an original preclinical study published in this issue of Blood Advances, Li et al 1 provide
proof-ofprinciple evidence of the therapeutic efficacy of a novel approach against multiple …

Proteomics: addressing the challenges of multiple myeloma

F Ge, S Tao, L Bi, Z Zhang… - Acta Biochim Biophys Sin, 2011 - academic.oup.com
Multiple myeloma (MM) is a malignancy of terminally differentiated B-lymphocytes that
accounts for∼ 13% of all hematologic cancers. Despite a wealth of knowledge describing …

Proteomics-inspired precision medicine for treating and understanding multiple myeloma

M Ho, G Bianchi, KC Anderson - Expert review of precision …, 2020 - Taylor & Francis
Introduction: Remarkable progress in molecular characterization methods has led to
significant improvements in how we manage multiple myeloma (MM). The introduction of …

Proteomic alteration in the progression of multiple myeloma: A comprehensive review

NH Ismail, A Mussa, MJ Al-Khreisat, S Mohamed Yusoff… - Diagnostics, 2023 - mdpi.com
Multiple myeloma (MM) is an incurable hematologic malignancy. Most MM patients are
diagnosed at a late stage because the early symptoms of the disease can be uncertain and …

[HTML][HTML] Targeting myeloma metabolism: How abnormal metabolism contributes to multiple myeloma progression and resistance to proteasome inhibitors

X Zhou, R He, WX Hu, S Luo, J Hu - Neoplasia, 2024 - Elsevier
Multiple myeloma is a hematological malignancy that has evolved from antibody-secreting B
lymphocytes. Like other types of cancers, myeloma cells have acquired functional …

Multiple myeloma metabolism–a treasure trove of therapeutic targets?

M Roman-Trufero, HW Auner, CM Edwards - Frontiers in Immunology, 2022 - frontiersin.org
Multiple myeloma is an incurable cancer of plasma cells that is predominantly located in the
bone marrow. Multiple myeloma cells are characterized by distinctive biological features that …