In the past few years, it has been made increasingly evident that nitric oxide (NO), a simple
gas with free radical chemical properties, plays a very important role in the pathology of the …

Many of the actions of nitric oxide are not due to nitric oxide itself, but rather by the
secondary formation of oxidants like peroxynitrite. Peroxynitrite leaves a footprint in the …

Nitric oxide and other reactive nitrogen species appear to play crucial roles in the brain such
as neuromodulation, neurotransmission and synaptic plasticity, but are also involved in …

Publisher Summary Nitric oxide (NO) is an important cellular messenger that helps regulate
cerebral blood flow and can modulate synaptic plasticity. NO is the only known biological …

Nitric oxide (NO) is reported to cause neuronal damage through various mechanisms. The
present study tests the hypothesis that NO synthase inhibition by Nω‐nitro‐l‐arginine …

Nitric oxide (NO) production increases during hypoxia/ischemia–reperfusion in the immature
brain and is associated with neurotoxicity. NO at physiologic concentrations has been …

Nitric oxide is a key bioregulatory agent in a wide variety of biological processes, yet it also
can have cytotoxic properties. This dichotomy raises the question of how this potentially toxic …

We evaluated the neuroprotective effect of the nitric oxide synthesis inhibitor, N G-nitro-L-
arginine in a neonatal hypoxic-ischemic rat model. Unilateral hypoxic-ischemic injury was …

We hypothesized that elimination of neuronal nitric oxide synthase (nNOS) by targeted
disruption of the nNOS gene would result in amelioration of damage seen after hypoxia …

Nitric oxide (NO) is a recently recognized messenger molecule that has been shown to
possess pleiotropic properties, including vasodilation, neurotransmission, cytotoxicity and …