This study is to prepare and evaluate Pluronics-modified mixed micelle (MM) to deliver
polyphenolic myricetin (MYR) across the blood-brain barrier. MYR has been proven to be an …

Purpose: Clinical applications of curcumin (Cur) have been greatly restricted due to its low
solubility and poor systemic bioavailability. Three-arm amphiphilic copolymer tricarballylic …

Purpose: To improve curcumin's pharmacokinetic, in vitro cytotoxicity and release property.
Methods: A novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) …

Quercetin (QT) is a plant polyphenol with various pharmacological properties. However, the
low water solubility limits its therapeutic efficacy. In the present study, QT-loaded sodium …

The blood–brain barrier represents an insurmountable obstacle for the therapy of central
nervous system related diseases. Polymeric micelles have many desirable properties for …

In this study, galactosamine-modified poly (ethylene glycol)-poly (lactide)(Gal-PEG-PLA)
polymers were synthesized and Gal-PEG-PLA/D-α-tocopherol polyethylene glycol 1000 …

Abstract Trans-Resveratrol (T-RES) is a compound with wide therapeutic applications that
shows low bioavailability and distribution across blood-brain barrier. The purpose of our …

In this study, glycyrrhetinic acid (GA) was conjugated with mono amino poly (ethylene glycol)-
b-poly (ε-caprolactone)(H 2 N-PEG-PCL) with succinate linker to obtain the GA-modified …

In this study, drug delivery system of gliclazide, a poorly soluble drug, was developed and
evaluated in vitro and in vivo. We synthesized five series of mPEG-PCL di block copolymers …

The effective treatment of brain cancer is hindered by the poor transport across the blood-
brain barrier (BBB) and the low penetration across the blood-tumour barrier (BTB). The main …