In the progression of liver disease, various metabolic disorders and inflammatory factors
cause dysfunction of intrahepatic leukocytes, but there is no research to summarize the …

Introduction Immune cells play crucial roles in the development of chronic hepatitis B virus
(HBV) infection, leading to cirrhosis and hepatocellular carcinoma (HCC). However, their …

Hepatitis B virus (HBV) infection playsa significant role in the etiology and progression of
liver‐relatedpathologies, encompassing chronic hepatitis, fibrosis, cirrhosis, and eventual …

Distinct populations of hepatocytes infected with hepatitis B virus (HBV) or only harboring
HBV DNA integrations coexist within an HBV chronically infected liver. These hepatocytes …

Background & Aims HBV infection is one of the leading causes of liver cirrhosis. However,
the immune microenvironment in patients with HBV cirrhosis remains elusive. Methods …

T cell functional plasticity helps tailor antiviral immunity during different phases of infections.
We tested whether, during different phases of HBV infection, virus-specific T cells can …

Abstract CD4+ T and regulatory T cells (Tregs) seem to play a key role in persistence of
hepatitis B virus (HBV) infection. However, the molecular events by which Tregs exert their …

Hepatitis B virus (HBV)-specific CD8+ T cells play a dominant role during acute-resolving
HBV infection but are functionally impaired during chronic HBV infection in humans. These …

Chronic viral hepatitis infections are a major public health concern, with an estimated 290
million individuals infected with hepatitis B virus (HBV) globally. This virus has been a …

Hepatitis B virus (HBV) remains a leading cause of liver-related morbidity and mortality
through chronic hepatitis that may progress to liver cirrhosis and cancer. The central role …