Exacerbation of methamphetamine neurotoxicity in cold and hot environments: neuroprotective effects of an antioxidant compound H-290/51

HS Sharma, EA Kiyatkin, R Patnaik, JV Lafuente… - Molecular …, 2015 - Springer
In this study, we examined the influence of cold and hot environments on methamphetamine
(METH) neurotoxicity in both drug-naive rats and animals previously exposed to different …

Evidence for a role of Hsp70 in the neuroprotection induced by heat shock pre‐treatment against 3, 4‐methylenedioxymethamphetamine toxicity in rat brain

I Escobedo, I Peraile, L Orio, MI Colado… - Journal of …, 2007 - Wiley Online Library
Methylenedioxymethamphetamine (MDMA,'ecstasy') produces acute hyperthermia which
increases the severity of the selective serotoninergic neurotoxicity produced by the drug in …

Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice

SF Ali, GD Newport, RR Holson, W Slikker Jr… - Brain research, 1994 - Elsevier
Recently we have reported that methamphetamine (METH) neurotoxicity in rats depends on
the environmental temperature. Here, we evaluate whether a cold environment (4° C) or …

nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice

Y Itzhak, JL Martin, SF Ali - Neuroreport, 2000 - journals.lww.com
Methamphetamine (METH)-induced dopaminergic neurotoxicity is associated with
hyperthermia. We investigated the effect of several neuronal nitric oxide synthase (nNOS) …

Expression of heat shock protein (HSP 72 kDa) during acute methamphetamine intoxication depends on brain hyperthermia: neurotoxicity or neuroprotection?

EA Kiyatkin, HS Sharma - Journal of neural transmission, 2011 - Springer
In the present study, light and electron microscopy were used to examine heat shock protein
(HSP 72kD) expression during acute methamphetamine (METH) intoxication in rats and …

[引用][C] Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice

SF Ali, GD Newport, RR Holson… - Annals of the New …, 1995 - Wiley Online Library
Methamphetamine (METH) is one of the major drugs of abuse shown to cause neurotoxicity
in rodents and nonhuman primates. Recently, we reported that METH neurotoxicity in rats …

Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51

HS Sharma, PO Sjoquist, SF Ali - Current pharmaceutical …, 2007 - ingentaconnect.com
The psychostimulants, morphine and methamphetamine are well known drugs of abuse that
induce brain pathology and/or neurodegeneration resulting in a huge burden on our society …

A single dose model of methamphetamine-induced neurotoxicity in rats: effects on neostriatal monoamines and glial fibrillary acidic protein

M Fukumura, GD Cappon, C Pu, HW Broening… - Brain research, 1998 - Elsevier
The neurotoxic effects of a single administration of methamphetamine (MA) were studied
under conditions conducive to MA-induced hyperthermia. After a single dose of MA (10, 20 …

Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude. Neuroprotective effects of nanodelivery of a potent antioxidant compound H …

HS Sharma, JV Lafuente, L Feng, DF Muresanu… - Progress in brain …, 2021 - Elsevier
Military personnel are often exposed to high altitude (HA, ca. 4500–5000 m) for combat
operations associated with neurological dysfunctions. HA is a severe stressful situation and …

Further studies of the role of hyperthermia in methamphetamine neurotoxicity.

JF Bowyer, DL Davies, L Schmued, HW Broening… - … of Pharmacology and …, 1994 - ASPET
The depletion of striatal dopamine (DA) that can occur after methamphetamine (METH)
administration has been linked to METH-induced hyperthermia. The relationship between …