Streptokinase Treatment Reverses Biofilm-Associated Antibiotic Resistance in Staphylococcus aureus

NP Jørgensen, N Zobek, C Dreier, J Haaber, H Ingmer… - Microorganisms, 2016 - mdpi.com
Biofilms formed by Staphylococcus aureus is a serious complication to the use of medical
implants. A central part of the pathogenesis relies on S. aureus' ability to adhere to host …

Tissue plasminogen activator coating on implant surfaces reduces Staphylococcus aureus biofilm formation

J Kwiecinski, M Na, A Jarneborn… - Applied and …, 2016 - Am Soc Microbiol
Staphylococcus aureus biofilm infections of indwelling medical devices are a major medical
challenge because of their high prevalence and antibiotic resistance. As fibrin plays an …

An Essential Role for Coagulase in Staphylococcus aureus Biofilm Development Reveals New Therapeutic Possibilities for Device-Related Infections

M Zapotoczna, H McCarthy, JK Rudkin… - The Journal of …, 2015 - academic.oup.com
High-level resistance to antimicrobial drugs is a major factor in the pathogenesis of chronic
Staphylococcus aureus biofilm–associated, medical device–related infections. Antimicrobial …

Staphylococcus aureus fibronectin binding protein A mediates biofilm development and infection

CM Gries, T Biddle, JL Bose, T Kielian… - Infection and …, 2020 - Am Soc Microbiol
Implanted medical device-associated infections pose significant health risks, as they are
often the result of bacterial biofilm formation. Staphylococcus aureus is a leading cause of …

Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation

J Kwiecinski, M Peetermans… - The Journal of …, 2016 - academic.oup.com
Staphylococcus aureus biofilms, a leading cause of persistent infections, are highly resistant
to immune defenses and antimicrobial therapies. In the present study, we investigated the …

Novel treatment of Staphylococcus aureus device-related infections using fibrinolytic agents

S Hogan, JP O'Gara, E O'Neill - Antimicrobial agents and …, 2018 - Am Soc Microbiol
Staphylococcal infections involving biofilms represent a significant challenge in the
treatment of patients with device-related infections. Staphylococcus aureus biofilms have …

Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials

CR Arciola, D Campoccia, P Speziale, L Montanaro… - Biomaterials, 2012 - Elsevier
Implant infections in orthopaedics, as well as in many other medical fields, are chiefly
caused by staphylococci. The ability of growing within a biofilm enhances the chances of …

Environmental factors modulate biofilm formation by Staphylococcus aureus

Y Liu, J Zhang, Y Ji - Science Progress, 2020 - journals.sagepub.com
Biofilm formation on indwelling medical devices represents an exclusive evasion
mechanism for many pathogenic bacteria to establish chronic infections. Staphylococcus …

Biology and regulation of staphylococcal biofilm

P François, J Schrenzel, F Götz - International journal of molecular …, 2023 - mdpi.com
Despite continuing progress in medical and surgical procedures, staphylococci remain the
major Gram-positive bacterial pathogens that cause a wide spectrum of diseases, especially …

Staphylococcus aureus biofilms: an opportunistic pathogen with multidrug resistance

G Silva-Santana, GG Cabral-Oliveira… - … and Research in …, 2021 - journals.lww.com
Studies related to bacterial biofilm formation are extremely relevant because of their
constant association with several human diseases. The organization of this sessile microbial …