Particulate matter toxicity is Nrf2 and mitochondria dependent: the roles of metals and polycyclic aromatic hydrocarbons

M Pardo, X Qiu, R Zimmermann… - Chemical research in …, 2020 - ACS Publications
Particulate matter (PM), an important component of air pollution, induces significant adverse
health effects. Many of the observed health effects caused by inhaled PM are associated …

Nrf2 protects against diverse PM2. 5 components-induced mitochondrial oxidative damage in lung cells

M Pardo, F Xu, M Shemesh, X Qiu, Y Barak… - Science of the Total …, 2019 - Elsevier
Nrf2 is an important transcription factor implicated in the oxidative stress response, which
has been reported to play an important role in the way by which air pollution particulate …

In vivo and in vitro evidence for the involvement of Nrf2-antioxidant response element signaling pathway in the inflammation and oxidative stress induced by …

M Radan, M Dianat, M Badavi, SA Mard… - Free radical …, 2019 - Taylor & Francis
Environmental pollution is one of the risk factors for respiratory diseases. The nuclear factor
erythroid 2-related factor 2 (Nrf2) is the major mechanisms contributing to cellular defense …

Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis: The role of Nrf2 and AhR-mediated pathways

AO Lawal - Toxicology letters, 2017 - Elsevier
Air particulate matter (PM) is an important component of air pollution, which has been
reported to play important role in the adverse health effects of the latter. Extensive …

Long-term exposure to PM2. 5 aggravates pulmonary fibrosis and acute lung injury by disrupting Nrf2-mediated antioxidant function

C Zhao, W Pu, J Wazir, X Jin, L Wei, S Song, Z Su… - Environmental …, 2022 - Elsevier
Epidemiological studies have indicated that exposure to ambient air-borne fine particulate
matter (PM2. 5) is associated with many cardiopulmonary diseases; however, the underlying …

Particulate matter induces tissue oxinflammation: from mechanism to damage

G Valacchi, N Magnani, B Woodby… - Antioxidants & Redox …, 2020 - liebertpub.com
Significance: Oxidative stress and oxidative damage are central hypothetical mechanisms
for the adverse effects of airborne particulate matter (PM). Activation of inflammatory cells …

Relationship between redox activity and chemical speciation of size-fractionated particulate matter

L Ntziachristos, JR Froines, AK Cho… - Particle and fibre toxicology, 2007 - Springer
Background Although the mechanisms of airborne particulate matter (PM) related health
effects remain incompletely understood, one emerging hypothesis is that these adverse …

Mitochondrial alterations triggered by repeated exposure to fine (PM2. 5-0.18) and quasi-ultrafine (PM0. 18) fractions of ambient particulate matter

J Sotty, J Kluza, C De Sousa, M Tardivel… - Environment …, 2020 - Elsevier
Nowadays ambient particulate matter (PM) levels still regularly exceed the guideline values
established by World Health Organization in most urban areas. Numerous experimental …

Composition of air pollution particles and oxidative stress in cells, tissues, and living systems

AJ Ghio, MS Carraway, MC Madden - Journal of Toxicology and …, 2012 - Taylor & Francis
Epidemiological studies demonstrated an association between increased levels of ambient
air pollution particles and human morbidity and mortality. Production of oxidants, either …

[HTML][HTML] Redox toxicology of environmental chemicals causing oxidative stress

F Zheng, FM Gonçalves, Y Abiko, H Li, Y Kumagai… - Redox biology, 2020 - Elsevier
Living organisms are surrounded with heavy metals such as methylmercury, manganese,
cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or …