Skeletal muscle insulin resistance is a prominent early feature in the pathogenesis of type 2
diabetes. In attempt to overcome this defect, we generated mice overexpressing insulin …

OBJECTIVE—Insulin resistance in skeletal muscle plays a critical role in the pathogenesis of
type 2 diabetes, yet the cellular mechanisms responsible for insulin resistance are poorly …

Impaired skeletal muscle insulin receptor function is a feature of common forms of insulin
resistance, including obesity and noninsulin-dependent diabetes mellitus. However, the …

Skeletal muscle insulin resistance is among the earliest detectable defects in humans with
type 2 diabetes mellitus. To determine the contribution of muscle insulin resistance to the …

Variations in skeletal muscle insulin signaling are thought to have important effects on in
vivo glucose homeostasis. To address the role of the insulin receptor in insulin action in …

Insulin and insulin-like growth factor 1 (IGF-1) are major regulators of muscle protein and
glucose homeostasis. To determine how these pathways interact, we generated mice with …

Obesity and insulin resistance in skeletal muscle are two major factors in the pathogenesis
of type 2 diabetes. Mice with muscle-specific inactivation of the insulin receptor gene …

Physical exercise promotes glucose uptake into skeletal muscle and makes the working
muscles more sensitive to insulin. To understand the role of insulin receptor (IR) signaling in …

Coordination of skeletal muscle growth and metabolism with nutrient availability is critical for
metabolic homeostasis. To establish the role of insulin-like signaling in this process, we …

Type 2 diabetes is a polygenic disease characterized by defects in both insulin secretion
and insulin action. We have previously reported that isolated insulin resistance in muscle by …