Historically, the development of antiviral drugs has lagged behind the development of other
antimicrobial agents. Since the early 1950s when the search began for antiviral agents, the …

The goal of any antiviral drug is to eradicate or inhibit the virion while producing minimal
effect on host cell function. Most antiviral medications will inhibit at least one step in the …

PROMISES TO KEEP: CLINICAL USE OF ANTIVIRAL DRUGS GJ GALASSO Office of the
Director, National Institutes of Health, Bethesda, Page 1 22 PROMISES TO KEEP: CLINICAL …

Viral diseases pose significant challenges in human and veterinary medicine, as effective
treatment options are limited. The development of antiviral drugs becomes increasingly …

Preview We have had “miracle drugs” for bacterial infection for more than half a century, but
viruses, not surprisingly, have proved to be hardier, more resistant organisms than bacteria …

Publisher Summary This chapter discusses the continuing search for antiviral drugs. Many
virus diseases, both of humans and animals, have been successfully controlled by vaccines …

Viruses are very simple micro-organisms consisting of a nucleic acid (the viral genome)
protected from the environment by a layer or layers of proteins. Most viruses, especially …

Existing and emerging viral central nervous system (CNS) infections are major sources of
human morbidity and mortality. Treatments of proven efficacy are currently limited …

Great advances have been made toward the control of infectious diseases in the past
century. They have ranged from improved sanitation and personal hygiene, to the control of …

Remarkable progress has been made in antiviral chemotherapy. Six approved antiviral
drugs are now available for the treatment of various viral infections. Trifluridine, idoxuridine …