Insights into the neurobiology of suicidality: explicating the role of glutamatergic systems through the lens of ketamine

AT Can, JS Mitchell, M Dutton… - Psychiatry and …, 2023 - Wiley Online Library
Suicidality is a prevalent mental health condition, and managing suicidal patients is one of
the most challenging tasks for health care professionals due to the lack of rapid‐acting …

[HTML][HTML] Eradicating suicide at its roots: preclinical bases and clinical evidence of the efficacy of ketamine in the treatment of suicidal behaviors

D De Berardis, M Fornaro, A Valchera… - International journal of …, 2018 - mdpi.com
Despite the continuous advancement in neurosciences as well as in the knowledge of
human behaviors pathophysiology, currently suicide represents a puzzling challenge. The …

[HTML][HTML] Pharmacological mechanism of ketamine in suicidal behavior based on animal models of aggressiveness and impulsivity: a narrative review

TML Nguyen, F Jollant, L Tritschler, R Colle… - Pharmaceuticals, 2023 - mdpi.com
Around 700,000 people die from suicide each year in the world. Approximately 90% of
suicides have a history of mental illness, and more than two-thirds occur during a major …

Ketamine and suicidal ideation in depression: Jumping the gun?

R Rajkumar, J Fam, EYM Yeo, GS Dawe - Pharmacological research, 2015 - Elsevier
Depression and suicide are known to be intricately entwined but the neurobiological basis
underlying this association is yet to be understood. Ketamine is an N-methyl d-aspartate …

Biological basis of suicide and suicidal behavior

GN Pandey - Bipolar disorders, 2013 - Wiley Online Library
Objective Suicide is a major public health concern as each year 30000 people die by
suicide in the USA alone. In the teenage population, it is the second leading cause of death …

Treatment response with ketamine in chronic suicidality: an open label functional connectivity study

AT Can, DF Hermens, AZ Mohamed, ZY Shan… - Journal of affective …, 2023 - Elsevier
Background Ketamine has recently been proposed as a treatment option for suicidality.
Whilst its mechanism of action has been explored at molecular levels, the effect on the brain …

[HTML][HTML] Neurobiological basis of increased risk for suicidal behaviour

A Wisłowska-Stanek, K Kołosowska, P Maciejak - Cells, 2021 - mdpi.com
According to the World Health Organization (WHO), more than 700,000 people die per year
due to suicide. Suicide risk factors include a previous suicide attempt and psychiatric …

[PDF][PDF] Neurobiological factors associated with suicidal behavior

B Lee, Y Kim - Psychiatry Investigation, 2006 - researchgate.net
Suicide is a major public health issue and a significant cause of death worldwide. Many
animal, postmortem, clinical, and genetic studies have produced results implicating at least …

The neurobiology of suicide and suicidality

K Van Heeringen - The Canadian Journal of Psychiatry, 2003 - journals.sagepub.com
Objective: To investigate the current state of knowledge regarding the neurobiology of
suicide and suicidality. Method: The literature on the neurobiology of suicidality and suicide …

The psychology and neurobiology of suicidal behavior

TE Joiner Jr, JS Brown, LRR Wingate - Annu. Rev. Psychol., 2005 - annualreviews.org
Suicide is a leading cause of death, but it is not well understood or well researched. Our
purpose in this review is to summarize extant knowledge on neurobiological and …