OBJECTIVE: To mathematically assess drug losses due to infusion line residuals and
evaluate methods to compensate for drug loss due to residual volumes in intravenous pump …

Background: Imipenem is a broad-spectrum β-lactam antibiotic frequently used for infectious
complications in ICU patients. Dosing optimisation still remains challenging for clinicians …

Sir, The combination of piperacillin and tazobactam has been shown to be efficacious for the
treatment of intra-abdominal infections, skin and soft tissue infections, bacteraemia and …

This study examined the effect of various levels of renal impairment on the probability of
achieving free drug concentrations that exceed the MIC for 50% of the dosing interval (50% f …

Optimal dosing of β-lactam antibiotics in critically ill patients is a challenge given the
unpredictable pharmacokinetic profile of this patient population. Several studies have shown …

Abstract Background and Objectives Although dose optimization studies have been
performed for piperacillin and tazobactam separately, a combined integral analysis is not yet …

Study Objective. To determine the appropriate compartmental and noncompartmental
pharmacokinetic parameters for intravenous piperacillin and tazobactam. Design …

Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …

Physiologically based pharmacokinetic (PBPK) models consist of compartments
representing different tissues. As most models are only verified based on plasma …