The percentage of the time that the free drug concentration remains above a concentration
threshold (% fT> concentration threshold) has frequently been identified to be the optimal …

Purpose The objective of this study was to evaluate the exposure and the pharmacodynamic
target attainment of piperacillin/tazobactam (PTZ) in adult critically ill patients. Methods We …

(1) Background: Piperacillin/tazobactam is a broad-spectrum antimicrobial encompassing
most Gram-positive and Gram-negative aerobic and anaerobic bacteria. The inappropriate …

Introduction Cefmetazole (CMZ) has gained interest as a carbapenem-sparing alternative to
the epidemic of extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL …

Background: Although intermittent bolus dosing is currently the standard of practice for many
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …

Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very
elderly patients. This study aimed to conduct a population pharmacokinetic analysis of CI …

Background: Prolonging the infusion of a β-lactam antibiotic enhances the time in which
unbound drug concentrations remain above the minimum inhibitory concentration (fT> MIC) …

Abstract Objectives: Pharmacokinetic (PK)/pharmacodynamic (PD) models have become
increasingly important in optimizing antimicrobial therapy. This approach is highly …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …

Infections are a major problem in patients with burn diseases. Mortality is high despite
antibiotic therapy as studies are controversial concerning drug underdosing. The aims of this …