Background: In 2017, a national drug shortage of small volume solutions significantly
affected the preparation of intravenous antibiotics. In response, a continuous infusion …

Recent studies have shown that the pharmacodynamic (PD) index driving the efficacy of β-
lactam/β-lactamase inhibitor combinations such as ceftazidime/avibactam and ceftolozane …

The objective of the current review was to provide an updated and comprehensive summary
on pharmacokinetic data describing the distribution of antimicrobials into interstitial fluid …

Administration of β-lactam antibiotics by extended infusion optimizes the pharmacodynamic
properties and bactericidal activity of these agents resulting in a potential improvement in …

Conclusions Zander and colleagues have provided new information on target attainment of
PIP concentrations in a heterogeneous group of critically ill patients. Among patients without …

This study analyzes the pharmacokinetic variability of piperacillin in non-critically ill patients
with Enterobacteriaceae bloodstream infections (EBSI) and explores predicted clinical …

Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-
lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models …

Study Objective To evaluate the pharmacokinetic and pharmacodynamic profiles of
piperacillin‐tazobactam administered as a 4‐hour infusion in critically ill patients undergoing …

Piperacillin sodium–tazobactam sodium, a β-lactam antimicrobial, is extensively used
because of its broad-spectrum activity against many enteric gram-negative pathogens …

What is known and objective Timely and appropriate dosing of antibiotics is essential for the
treatment of bacterial sepsis. Critically ill patients treated with continuous kidney …