Objectives The aim of this study was to characterise a novel tet (X6)-carrying plasmid
detected in a livestock-associated Acinetobacter towneri isolate. Methods PCR screening …

Tigecycline is the antibiotic of last resort for the treatment of extensively drug-resistant
bacterial infections, mainly those of multidrug-resistant Gram-negative bacteria. The plasmid …

The emergence of high-level tigecycline resistance mediated by plasmid-borne tet (X) genes
greatly threatens the clinical effectiveness of tigecycline. However, the dissemination pattern …

Antibiotic-resistant bacteria are emerging all the time, but the continued emergence of novel
resistance genes and genetic structures is even more alarming. Tigecycline is currently the …

The recent emergence of plasmid-mediated tigecycline resistance gene tet (X) has
challenged the clinical effectiveness of tigecycline as a last-resort treatment option. During …

To investigate the contribution of a tet (A) variant to tigecycline resistance in Enterobacter
hormaechei and the recombination events that occurred during transmission of this variant …

The emergence of the tet (X) gene is a severe challenge to global public health security, as
clinical tigecycline resistance shows a rapidly rising trend. In this research, we identified two …

ABSTRACT A novel, plasmid-mediated, high-level tigecycline resistance tet (X) gene
variant, tet (X5), was detected in a clinical Acinetobacter baumannii isolate from China in …

The emergence of plasmid-mediated tigecycline resistance genes has attracted a great deal
of attention globally. Currently, no comprehensive in-depth genomic epidemiology study of …

The emergence of the plasmid-mediated high levels of the tigecycline resistance gene has
drawn worldwide attention and has posed a major threat to public health. In this study, we …