The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators
of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal …

Maintenance of the differentiated state and cell cycle exit in adult Sertoli cells depends on
tumor suppressor retinoblastoma protein (RB, also known as RB1). We have previously …

The retinoblastoma protein (RB) is essential for normal cell cycle control. RB function
depends, at least in part, on interactions with the E2F family of DNA-binding transcription …

Retinoblastoma protein (RB) plays crucial roles in cell cycle control and cellular
differentiation. Specifically, RB impairs the G1 to S phase transition by acting as a repressor …

E2F1 is a crucial downstream effector of the retinoblastoma protein (pRB) pathway. To
address the consequences of short-term increase in E2F1 activity in adult tissues, we …

Simple Summary Male fertility relies on the generation of functional sperm in seminiferous
tubules of the testis. In mammals, Sertoli cells are the only somatic cells that directly interact …

Continual spermatogenesis is the cornerstone of male fertility and relies on the actions of an
undifferentiated spermatogonial population comprised of stem cells and progenitors. A …

The retinoblastoma gene, RB-1, was the first identified tumor suppressor. Rb−/− mice die in
mid-gestation with defects in proliferation, differentiation and apoptosis. The activating E2F …

The retinoblastoma tumor suppressor, pRb, restricts cell-cycle progression mainly by
regulating members of the E2F-transcription-factor family. The Rb pathway is often …

The retinoblastoma tumor suppressor (RB) is a critical regulator of E2F-dependent
transcription, controlling a multitude of protumorigenic networks including but not limited to …