Impact of chrysin on the molecular mechanisms underlying diabetic complications

T Farkhondeh, S Samarghandian… - Journal of cellular …, 2019 - Wiley Online Library
Diabetes mellitus is a chronic metabolic disorder, resulting in high morbidity and mortality
worldwide. Neuropathy, ocular diseases, kidney diseases, and cardiovascular disease are …

Antidiabetic properties of dietary chrysin: a cellular mechanism review

RM Dewi, M Megawati, LD Antika - Mini Reviews in Medicinal …, 2022 - ingentaconnect.com
Diabetes mellitus is the most common chronic metabolic disorder and is considered one of
the leading causes of morbidity and mortality. The improperly-treated chronic hyperglycemia …

Chrysin induces antidiabetic, antidyslipidemic and anti-inflammatory effects in athymic nude diabetic mice

JJ Ramírez-Espinosa, J Saldaña-Ríos… - Molecules, 2017 - mdpi.com
Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper
treatment to stop degenerative changes derived from this disease. In this context, chrysin (5 …

Promising protective effects of chrysin in cardiometabolic diseases

M Talebi, M Talebi, T Farkhondeh… - Current Drug …, 2022 - ingentaconnect.com
Cardiometabolic diseases (CMD) have caused a great burden in terms of morbidity and
mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension …

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

M Talebi, M Talebi, T Farkhondeh… - Cancer Cell …, 2021 - Springer
Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has
anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and …

Chrysin induces death of prostate cancer cells by inducing ROS and ER stress

S Ryu, W Lim, FW Bazer, G Song - Journal of cellular …, 2017 - Wiley Online Library
Chrysin is a natural flavone found in numerous plant extracts, honey, and propolis that has
multiple biological activities including anti‐cancer effects. Understanding of biological …

Dietary compound chrysin inhibits retinal neovascularization with abnormal capillaries in db/db mice

MK Kang, SH Park, YH Kim, EJ Lee, LD Antika, DY Kim… - Nutrients, 2016 - mdpi.com
Diabetic retinopathy (DR) develops in a significant proportion of patients with chronic
diabetes, characterized by retinal macular edema and abnormal retinal vessel outgrowth …

[HTML][HTML] An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches

M Talebi, M Talebi, T Farkhondeh… - Biomedicine & …, 2021 - Elsevier
Neurological diseases are responsible for a large number of morbidities and mortalities in
the world. Flavonoids are phytochemicals that possess various health-promoting impacts …

Chrysin ameliorates diabetes-associated cognitive deficits in Wistar rats

R Li, A Zang, L Zhang, H Zhang, L Zhao, Z Qi… - Neurological …, 2014 - Springer
Chrysin (CH) is an important natural plant flavonoid and possesses diverse pharmacological
activities. Our present investigations aimed to assess the neuroprotection of CH against …

Chrysin ameliorates STZ-induced diabetes in rats: possible impact of modulation of TLR4/NF-κβ pathway

A Salama, GF Asaad, A Shaheen - Research in pharmaceutical …, 2022 - journals.lww.com
Background and purpose: Growing evidence advocates that upregulation of toll-like receptor
4 (TLR4) has been suggested as a causative influence in the development and …