Mechanical or physical cues are associated with the growth and differentiation of embryonic
stem cells (ESCs). While the substrate stiffness or topography independently affects the …

Recent approaches have utilized microfabricated platforms to examine combinations of
microenvironmental signals that regulate stem and progenitor cell differentiation. However …

Human livers have maturational lineages of cells within liver acini, beginning periportally in
stem cell niches, the canals of Hering, and ending in polyploid hepatocytes pericentrally and …

Obtaining functional hepatocytes from human pluripotent stem cells (hPSCs) holds great
potential for applications in drug safety testing, as well in the field of regenerative medicine …

Early embryonic stem cell (ESC) differentiation is marked by the formation of three germ
layers from which all tissues types arise. Conventionally, ESCs are differentiated by altering …

Embryonic stem cells (ESC) are excellent cell culture systems for elucidating developmental
signals that may be part of the stem cell niche. Although stem cells are traditionally induced …

Pluripotent embryonic stem cells represent a promising renewable cell source to generate a
variety of differentiated cell types including hepatocyte lineage cells, and may ultimately be …

The maintenance of stem cell pluripotency or stemness is crucial to embryonic development
and differentiation. The mechanical or physical microenvironment of stem cells, which …

A significant clinical need exists to differentiate human pluripotent stem cells (hPSCs) into
cardiomyocytes, enabling tissue modeling for in vitro discovery of new drugs or cell-based …

The self-organization of embryonic stem cells (ESCs) into organized tissues with three
distinct germ layers is critical to morphogenesis and early development. While the regulation …