Encapsulation of donor islets using a hydrogel material is a well-studied strategy for islet
transplantation, which protects donor islets from the host immune response. Replacement of …

Mechanical forces are critical to embryogenesis, specifically, in the lineage-specification
gastrulation phase, whereupon the embryo is transformed from a simple spherical ball of …

Research on human embryonic stem cells (hESCs) has attracted much attention given their
great potential for tissue regenerative therapy and fundamental developmental biology …

Reaping the promise of human embryonic stem (hES) cells hinges on effective defined
culture conditions. Efforts to identify chemically defined environments for hES cell …

The stiffness of hydrogels has been reported to direct cell fate. Here, we found that the
stiffness of hydrogels promotes the reprogramming of mouse embryonic fibroblasts into …

In vitro human liver models are essential for drug screening, disease modeling, and cell-
based therapies. Induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (iHeps) …

Matrix stiffening is one of the major risk factors for hepatocellular carcinoma (HCC) and
drives tumor progression. The extracellular matrix (ECM) stiffness of HCC displays …

Abstract 3D microenvironments provide a unique opportunity to investigate the impact of
intrinsic mechanical signaling on progenitor cell differentiation. Using a hydrogel‐based …

Angiocrine signals during the development and growth of organs, including the liver,
intestine, lung, and bone, are essential components of intercellular communication. The …

Microenvironmental factors, including substrate stiffness, regulate stem cell behavior and
differentiation. However, the effects of substrate stiffness on the behavior of induced …