Capsule stiffness regulates the efficiency of pancreatic differentiation of human embryonic stem cells
Encapsulation of donor islets using a hydrogel material is a well-studied strategy for islet
transplantation, which protects donor islets from the host immune response. Replacement of …
transplantation, which protects donor islets from the host immune response. Replacement of …
[HTML][HTML] Mechanics regulates fate decisions of human embryonic stem cells
Research on human embryonic stem cells (hESCs) has attracted much attention given their
great potential for tissue regenerative therapy and fundamental developmental biology …
great potential for tissue regenerative therapy and fundamental developmental biology …
Matrix stiffening facilitates stemness of liver cancer stem cells by YAP activation and BMF inhibition
D Ma, Q Luo, G Song - Biomaterials Advances, 2024 - Elsevier
Matrix stiffening is one of the major risk factors for hepatocellular carcinoma (HCC) and
drives tumor progression. The extracellular matrix (ECM) stiffness of HCC displays …
drives tumor progression. The extracellular matrix (ECM) stiffness of HCC displays …
Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal
Reaping the promise of human embryonic stem (hES) cells hinges on effective defined
culture conditions. Efforts to identify chemically defined environments for hES cell …
culture conditions. Efforts to identify chemically defined environments for hES cell …
Stiffness of hydrogels regulates cellular reprogramming efficiency through mesenchymal‐to‐epithelial transition and stemness markers
The stiffness of hydrogels has been reported to direct cell fate. Here, we found that the
stiffness of hydrogels promotes the reprogramming of mouse embryonic fibroblasts into …
stiffness of hydrogels promotes the reprogramming of mouse embryonic fibroblasts into …
Microtissue geometry and cell‐generated forces drive patterning of liver progenitor cell differentiation in 3D
Abstract 3D microenvironments provide a unique opportunity to investigate the impact of
intrinsic mechanical signaling on progenitor cell differentiation. Using a hydrogel‐based …
intrinsic mechanical signaling on progenitor cell differentiation. Using a hydrogel‐based …
Modulation of human iPSC-derived hepatocyte phenotype via extracellular matrix microarrays
In vitro human liver models are essential for drug screening, disease modeling, and cell-
based therapies. Induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (iHeps) …
based therapies. Induced pluripotent stem cell (iPSC)-derived hepatocyte-like cells (iHeps) …
Stiffness‐Tunable Hydrogel‐Sandwich Culture Modulates the YAP‐Mediated Mechanoresponse in Induced‐Pluripotent Stem Cell Embryoid Bodies and Augments …
P Nattasit, K Niibe, M Yamada… - Macromolecular …, 2023 - Wiley Online Library
Microenvironmental factors, including substrate stiffness, regulate stem cell behavior and
differentiation. However, the effects of substrate stiffness on the behavior of induced …
differentiation. However, the effects of substrate stiffness on the behavior of induced …
[HTML][HTML] Mesenchymal morphogenesis of embryonic stem cells dynamically modulates the biophysical microtissue niche
MA Kinney, R Saeed, TC McDevitt - Scientific reports, 2014 - nature.com
Stem cell fate and function are dynamically modulated by the interdependent relationships
between biochemical and biophysical signals constituting the local 3D microenvironment …
between biochemical and biophysical signals constituting the local 3D microenvironment …
Nanotopographical control for maintaining undifferentiated human embryonic stem cell colonies in feeder free conditions
D Bae, SH Moon, BG Park, SJ Park, T Jung, JS Kim… - Biomaterials, 2014 - Elsevier
Recently emerging evidence has indicated surface nanotopography as an important
physical parameter in the stem cell niche for regulating cell fate and behaviors for various …
physical parameter in the stem cell niche for regulating cell fate and behaviors for various …