Differentiation of stem cells into neurogenic lineage is of great interest for treatment of
neurodegenerative diseases. While the role of chemical cues in regulating stem cell fate is …

The success in driving embryonic stem cells towards hepatic lineage has been confounded
by the complexity and cost of differentiation protocols that employ large quantities of …

Traditional methods to assess hMSCs differentiation typically require long-term culture until
cells show marked expression of histological markers such as lipid accumulation inside the …

The physiological microenvironment of the stem cell niche, including the three factors of
stiffness, topography, and dimension, is crucial to stem cell proliferation and differentiation …

Epithelial cellular heterogeneity has been observed in pathological tissues with abnormal
matrix stiffness and cells cultured on rigid substrates. However, it remains unclear how …

Stem cell clusters, such as embryoid bodies (EBs) derived from embryonic stem cells, are
extensively studied for creation of multicellular clusters and complex functional tissues. It is …

Derivation of definitive endoderm (DE) from human embryonic stem cells (hESCs) can
address the needs of regenerative medicine for endoderm‐derived organs such as the …

Lumenogenesis within the epiblast represents a critical step in early human development,
priming the embryo for future specification and patterning events. However, little is known …

Objective To study the effects of different substrate stiffness on human hepatocytes using
RNA sequencing (RNA-Seq) technology. The stiffness was corresponding to physiology and …

Physical cues, such as cell microenvironment stiffness, are known to be important factors in
modulating cellular behaviors such as differentiation, viability, and proliferation. Apart from …