Stem cells are known to differentiate in response to the chemical and mechanical properties
of the substrates on which they are cultured. Thus, supramolecular biomaterials with tunable …

Pluripotent embryonic stem cells (ESCs) are capable of differentiating into all mesoderm-
derived cell lineages, including endothelial, hematopoietic, and cardiac cell types. Common …

Liver tissue engineering is promising as an alternative strategy to treat liver failure. However,
generating functional hepatocytes from stem cells is conventionally restricted by the …

Human pluripotent stem cells (hPSCs) are of great interest in biology and medicine due to
their ability to self-renew and differentiate into any adult or fetal cell type. Important efforts …

Human embryonic stem cells demonstrate a unique ability to respond to morphogens in vitro
by self-organizing patterns of cell fate specification that correspond to primary germ layer …

Embryonic stem cells hold considerable promise in tissue engineering and regenerative
medicine as a source of tissue-specific cells. However, realizing this promise requires novel …

Micropatterned biomaterial-based hydrogel platforms allow the recapitulation of in vivo-like
microstructural and biochemical features that are critical physiological regulators of stem cell …

The extracellular matrix (ECM) is mechanically inhomogeneous due to the presence of a
wide spectrum of biomacromolecules and hierarchically assembled structures at the …

The study of the liver progenitor cell microenvironment has demonstrated the important roles
of both biochemical and biomechanical signals in regulating the progenitor cell functions …

Organoids are lumen‐containing multicellular structures that recapitulate key features of the
organs, and are increasingly used in models of disease, drug testing, and regenerative …