Revealing the mechanisms of cell fate regulation is important for scientific research and
stem cell-based therapy. The traditional two-dimensional (2D) cultured mES cells are in a …

Matrix viscoelastic properties have been shown to have important effects on cell functions.
However, the conventional culture methods for investigating the influences of viscoelastic …

Both human pluripotent stem cells (hPSCs) from embryonic stem cells (hESCs) and induced
pluripotent stem cells (hiPSCs) have the potential ability to differentiate into many different …

The expansive growth and differentiation potential of human embryonic stem cells (hESCs)
make them a promising source of cells for regenerative medicine. However, this promise is …

Cardiomyocytes derived from human embryonic stem cells (hESC-CMs) are regarded as a
promising source for regenerative medicine, drug testing and disease modeling …

Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …

In many cell types, several cellular processes, such as differentiation of stem/precursor cells,
maintenance of differentiated phenotype, motility, adhesion, growth, and survival, strictly …

Hepatocytes, the main epithelial cell type in the liver, perform most of the biochemical
functions of the liver. Thus, maintenance of a primary hepatocyte phenotype is crucial for …

Dimensionality can have a profound impact on stiffness-mediated differentiation of
mesenchymal stem cells (MSCs). However, while we have begun to understand cellular …

Growing evidence suggests that physical microenvironments and mechanical stresses, in
addition to soluble factors, help direct mesenchymal-stem-cell fate. However, biological …