Strain-specific parallel evolution drives short-term diversification during Pseudomonas aeruginosa biofilm formation
KE McElroy, JGK Hui, JKK Woo… - Proceedings of the …, 2014 - National Acad Sciences
Generation of genetic diversity is a prerequisite for bacterial evolution and adaptation. Short-
term diversification and selection within populations is, however, largely uncharacterised, as …
term diversification and selection within populations is, however, largely uncharacterised, as …
[HTML][HTML] Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype
JG Thöming, J Tomasch, M Preusse, M Koska… - npj Biofilms and …, 2020 - nature.com
Studying parallel evolution of similar traits in independent within-species lineages provides
an opportunity to address evolutionary predictability of molecular changes underlying …
an opportunity to address evolutionary predictability of molecular changes underlying …
Polygenic Adaptation and Clonal Interference Enable Sustained Diversity in Experimental Pseudomonas aeruginosa Populations
How biodiversity arises and can be maintained in asexual microbial populations growing on
a single resource remains unclear. Many models presume that beneficial genotypes will …
a single resource remains unclear. Many models presume that beneficial genotypes will …
[HTML][HTML] Evolution and Adaptation in Pseudomonas aeruginosa Biofilms Driven by Mismatch Repair System-Deficient Mutators
Pseudomonas aeruginosa is an important opportunistic pathogen causing chronic airway
infections, especially in cystic fibrosis (CF) patients. The majority of the CF patients acquire …
infections, especially in cystic fibrosis (CF) patients. The majority of the CF patients acquire …
Spatial transcriptomes within the Pseudomonas aeruginosa biofilm architecture
Y Heacock‐Kang, Z Sun, J Zarzycki‐Siek… - Molecular …, 2017 - Wiley Online Library
Bacterial cooperative associations and dynamics in biofilm microenvironments are of special
interest in recent years. Knowledge of localized gene‐expression and corresponding …
interest in recent years. Knowledge of localized gene‐expression and corresponding …
[HTML][HTML] Biofilm associated genotypes of multiple antibiotic resistant Pseudomonas aeruginosa
J Redfern, J Wallace, A van Belkum, M Jaillard… - BMC genomics, 2021 - Springer
Background Pseudomonas aeruginosa is a ubiquitous environmental microorganism and
also a common cause of infection. Its ability to survive in many different environments and …
also a common cause of infection. Its ability to survive in many different environments and …
[HTML][HTML] Genetic determinants of Pseudomonas aeruginosa fitness during biofilm growth
S Schinner, F Engelhardt, M Preusse, JG Thöming… - Biofilm, 2020 - Elsevier
Pseudomonas aeruginosa is an environmental bacterium and an opportunistic human
pathogen. It is also a well-established model organism to study bacterial adaptation to …
pathogen. It is also a well-established model organism to study bacterial adaptation to …
Temperate phages both mediate and drive adaptive evolution in pathogen biofilms
EV Davies, CE James, D Williams… - Proceedings of the …, 2016 - National Acad Sciences
Temperate phages drive genomic diversification in bacterial pathogens. Phage-derived
sequences are more common in pathogenic than nonpathogenic taxa and are associated …
sequences are more common in pathogenic than nonpathogenic taxa and are associated …
Environmental heterogeneity drives within-host diversification and evolution of Pseudomonas aeruginosa
T Markussen, RL Marvig, M Gómez-Lozano, K Aanæs… - MBio, 2014 - Am Soc Microbiol
Microbial population polymorphisms are commonly observed in natural environments,
including long-term infected hosts. However, the underlying processes promoting and …
including long-term infected hosts. However, the underlying processes promoting and …
[HTML][HTML] An integrated model system to gain mechanistic insights into biofilm-associated antimicrobial resistance in Pseudomonas aeruginosa MPAO1
AR Varadarajan, RN Allan, JDP Valentin… - npj Biofilms and …, 2020 - nature.com
Pseudomonas aeruginosa MPAO1 is the parental strain of the widely utilized transposon
mutant collection for this important clinical pathogen. Here, we validate a model system to …
mutant collection for this important clinical pathogen. Here, we validate a model system to …