Genome sequencing of bacterial pathogens has advanced our understanding of their
evolution, epidemiology, and response to antibiotic therapy. However, we still have only a …

Background Small colony variants (SCVs) are slow-growing bacteria, which often show
increased resistance to antibiotics and cause latent or recurrent infections. It is therefore …

Background Bacteria employ a variety of adaptation strategies during the course of chronic
infections. Understanding bacterial adaptation can facilitate the identification of novel drug …

Background Pseudomonas aeruginosa ATCC 27853 was isolated from a hospital blood
specimen in 1971 and has been widely used as a model strain to survey antibiotics …

Many bacterial species are capable of biofilm growth, in which cells live and replicate within
multicellular community groups. Recent work shows that biofilm growth by a wide variety of …

Comparative genomics has greatly facilitated the identification of shared as well as unique
features among individual cells or tissues, and thus offers the potential to find disease …

Pseudomonas aeruginosa is an environmental microorganism and a causative agent of
diverse acute and chronic, biofilm‐associated infections. Advancing research‐based …

Antimicrobial resistance has been estimated to be responsible for over 700,000 deaths per
year; therefore, new antimicrobial therapies are urgently needed. One way to increase the …

The ecological and evolutionary forces that promote and maintain diversity in biofilms are
not well understood. To quantify these forces, three Pseudomonas aeruginosa populations …

Combination therapy is a common antibiotic treatment strategy that aims at minimizing the
risk of resistance evolution in several infectious diseases. Nonetheless, evidence supporting …