New insights to the ubiquitin–proteasome pathway (UPP) mechanism during spermatogenesis

CC Hou, WX Yang - Molecular biology reports, 2013 - Springer
Spermatogenesis is a complicated and highly ordered process which begins with the
differentiation of spermatogonial stem cells and ends with the formation of mature sperm …

Ubiquitin-proteasome system–regulated protein degradation in spermatogenesis

Y Xiong, C Yu, Q Zhang - Cells, 2022 - mdpi.com
Spermatogenesis is a prolonged and highly ordered physiological process that produces
haploid male germ cells through more than 40 steps and experiences dramatic …

Ubiquitin–proteasome system in spermatogenesis

R Bose, G Manku, M Culty, SS Wing - … protein modifications in the …, 2014 - Springer
Spermatogenesis represents a complex succession of cell division and differentiation events
resulting in the continuous formation of spermatozoa. Such a complex program requires …

Ubiquitination regulates the morphogenesis and function of sperm organelles

N Nakamura - Cells, 2013 - mdpi.com
It is now understood that protein ubiquitination has diverse cellular functions in eukaryotes.
The molecular mechanism and physiological significance of ubiquitin-mediated processes …

Expression of the ubiquitin proteasome system in neonatal rat gonocytes and spermatogonia: role in gonocyte differentiation

G Manku, SS Wing, M Culty - Biology of Reproduction, 2012 - academic.oup.com
The ubiquitin proteasome system (UPS) consists of a cascade of enzymatic reactions
leading to the ubiquitination of proteins, with consequent degradation or altered functions of …

Compartmentalization of the proteasome-interacting proteins during sperm capacitation

M Zigo, P Manaskova-Postlerova, V Jonakova… - Scientific Reports, 2019 - nature.com
Ubiquitination is a stable, reversible posttranslational modification of target proteins by
covalent ligation of the small chaperone protein ubiquitin. Most commonly ubiquitination …

The role of deubiquitinating enzymes in spermatogenesis

B Suresh, J Lee, SH Hong, KS Kim… - Cellular and molecular …, 2015 - Springer
Spermatogenesis is a complex process through which spermatogonial stem cells undergo
mitosis, meiosis, and cell differentiation to generate mature spermatozoa. During this …

[PDF][PDF] Sperm proteasome and fertilization

P Sutovsky - Reproduction, 2011 - Citeseer
The omnipresent ubiquitin–proteasome system (UPS) is an ATP-dependent enzymatic
machinery that targets substrate proteins for degradation by the 26S proteasome by tagging …

The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis

JH Richburg, JL Myers, SB Bratton - Seminars in cell & developmental …, 2014 - Elsevier
The ubiquitination of proteins is a post-translational modification that was first described as a
means to target misfolded or unwanted proteins for degradation by the proteasome. It is now …

Modifications of the 26S proteasome during boar sperm capacitation

M Zigo, K Kerns, M Sutovsky, P Sutovsky - Cell and tissue research, 2018 - Springer
Protein ubiquitination is a stable, reversible post-translational modification, targeting
proteins for degradation/recycling by the 26S proteasome in a well-characterized enzymatic …