Genetics and environmental exposures at critical developmental windows, play an important
role in the development of asthma. Genetically, asthma is a complex trait with known genes …

Background Asthma is characterized by airflow limitation and airway reactivity (AR).
Interleukin-13 (IL-13) is involved in the pathogenesis of asthma. Two functional SNPs …

The environment appears to play an important role in causing asthma, as evidenced by
increased disease prevalence accompanied by geographical differences 1, 2 and a small …

Background The occurrence of asthma is weakly explained by known genetic variants.
Epigenetic marks, DNA methylation (DNA-M) in particular, are considered to add to the …

Background Asthma heritability has only been partially explained by genetic variants and is
known to be sensitive to environmental factors, implicating epigenetic modifications such as …

Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …

Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …

Epigenome-wide studies of methylation in children support a role for epigenetic
mechanisms in asthma; however, studies in adults are rare and few have examined non …

Background Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may
interact with epigenetic factors including DNA methylation. We hypothesized that …

Asthma is a complex trait, often associated with atopy. The genetic contribution has been
evidenced by familial occurrence. Genome-wide association studies allowed for associating …