Objective Chronic rhinosinusitis (CRS) refractory to therapeutic intervention may involve a
particularly resistant infection known as a bacterial biofilm. Critical to biofilm formation is the …

Taste receptors are well known for their role in communicating information from the tongue
to the brain about nutritional value or potential toxicity of ingested substances. More recently …

Taste receptors on the tongue communicate information to the brain about the nutrient
content or potential toxicity of ingested foods. However, recent research has now shown that …

Innate and adaptive defense mechanisms protect the respiratory system from attack by
microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the …

Background Maintaining a clean upper respiratory tract requires efficient detection of
pathogenic bacteria so that the airway mucosa can mount proper defenses to neutralize and …

Background Recent evidence implicates polymorphisms of the bitter taste receptor
TAS2R38 as defining characteristics in respiratory innate defense that may contribute to the …

Bitter (T2R) and sweet (T1R) taste receptors have been implicated in sinonasal innate
immunity and in the pathophysiology of chronic rhinosinusitis (CRS). Taste receptors are …

Bitter (T2R) and sweet taste (T1R) receptors have emerged as regulators of upper airway
immune responses. Genetic variation of these taste receptors additionally confers …

Background We recently demonstrated the bitter taste receptor T2R38 upregulates
sinonasal mucosal innate defense in response to gram‐negative quorum‐sensing …

These recent studies identify a role for T2R38 in sinonasal innate immunity and chronic
rhinosinusitis. Clinical implications include the potential development of T2R38-directed …